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How to get fromDes Moines to Roanokeby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Des Moines to Roanoke by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Roanoke Regional Airport-Woodrum Field

    best
    1. Fly from Des Moines (DSM) to Roanoke Regional Airport-Woodrum Field (ROA)plane plane DSM - ROA
    5h 55m
    $122–576

  2. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Roanoke Bus Stopbus bus
    25h 20m
    $158–314

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Roanoketrain train
    29h 33m
    $255–551

  4. Drive 935.4 mi

    1. Drive from Des Moines to Roanokecar car 935.4 mi
    16h 26m
    $171–247

  5. Fly to Greenbrier Valley Airport, drive

    1. Fly from Des Moines (DSM) to Greenbrier Valley Airport (LWB)plane plane DSM - LWB
    2. Drive from Greenbrier Valley Airport (LWB) to Roanokecar car
    7h 19m
    $130–590

  6. Bus, train via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Charlottesvilletrain train
    3. Take the train from Charlottesville to Roanoketrain train
    32h 27m
    $287–637

Des Moines to Roanoke by bus

Calendar5Weekly Buses
Duration25h 20mAverage Duration
Ticket$158Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Roanoke.ExpandLaunch map view
  • Distance: 798.9 mi
  • Duration: 5h 55m

What companies run services between Des Moines, IA, USA and Roanoke, VA, USA?

American Airlines, Delta, and United Airlines fly from Des Moines (DSM) to Roanoke Regional Airport-Woodrum Field (ROA) every 2 hours. Alternatively, you can take a bus from Des Moines to Roanoke Bus Stop via St Louis Bus Station and Nashville Bus Station in around 25h 20m.

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