There are 5 ways to get from Des Moines to Saint Charles by plane, bus (Greyhound), bus, train, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane DSM - STL
5h$133–677Drive 310.1 mi
cheapest- Drive from Des Moines to Saint Charlescar 310.1 mi
6h 19m$57–82Bus
- Take the bus from Des Moines to Kansas Citybus Jefferson Lines 803 / ...
- Take the bus from Kansas City Bus Station to St Louis Bus Stationbus Greyhound US0180s / ...
10h 28m$90–139Bus, train via Kansas City
- Take the bus from Des Moines to Kansas City Bus Stationbus Greyhound US0156
- Take the train from Kansas City to St. Louistrain Missouri River Runner / ...
12h 1m$104–212Bus, train
- Take the bus from Des Moines to Bloomington-Normalbus Greyhound US0157S
- Take the train from Bloomington-Normal to St. Louistrain Lincoln Service / ...
11h 30m$89–165
Des Moines to Saint Charles by bus
Comparing Your Travel Options
The cheapest way to get from Des Moines to Saint Charles is to drive which costs $55 - $85 and takes 6h 19m.
The fastest way to get from Des Moines to Saint Charles is to fly which takes 5h and costs $130 - $700.
No, there is no direct bus from Des Moines to Saint Charles. However, there are services departing from Des Moines and arriving at 4375 Rider Trail North Sb via Kansas City Bus Station, Civic Center Transit Center and North Hanley Transit Center. The journey, including transfers, takes approximately 10h 28m.
The distance between Des Moines and Saint Charles is 282 miles. The road distance is 311.9 miles.
The best way to get from Des Moines to Saint Charles without a car is to bus which takes 10h 28m and costs $85 - $140.
It takes approximately 5h to get from Des Moines to Saint Charles, including transfers.
Des Moines to Saint Charles bus services, operated by Jefferson Lines, depart from Des Moines station.
The best way to get from Des Moines to Saint Charles is to fly which takes 5h and costs $130 - $700. Alternatively, you can bus, which costs $85 - $140 and takes 10h 28m.
Des Moines to Saint Charles bus services, operated by Jefferson Lines, arrive at Kansas City station.
Yes, the driving distance between Des Moines to Saint Charles is 312 miles. It takes approximately 6h 19m to drive from Des Moines to Saint Charles.
What companies run services between Des Moines, IA, USA and Saint Charles, MO, USA?
Southwest Airlines, United Airlines, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Des Moines to 4375 Rider Trail North Sb via Kansas City, Kansas City Bus Station, St Louis Bus Station, Civic Center Transit Center, and North Hanley Transit Center in around 10h 28m.
- Website
- aa.com
Flights from Des Moines to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 29m
- When
- Every day
- Estimated price
- $180–850
Flights from Des Moines to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 30m
- When
- Every day
- Estimated price
- $110–650
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $70–160
- Website
- Amtrak
Train from Bloomington-Normal to St. Louis
- Ave. Duration
- 2h 45m
- Frequency
- 5 times a day
- Estimated price
- $40–90
- Website
- Amtrak
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Des Moines to Kansas City
- Ave. Duration
- 3h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–75
- Book at
- Jefferson Lines
- Adult
- $50–75
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Booking & Getting There
There are 233+ hotels available in Saint Charles.