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How to get fromDes Moines to Saint Charlesby plane, bus, train, or car

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There are 5 ways to get from Des Moines to Saint Charles by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Chicago O'Hare International Airport, bus

    best
    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2. Take the bus from Rosemont CTA Station to Elgin Transportation Center Bay 4bus bus
    3h 34m
    $112–455

  2. Drive 293.4 mi

    cheapest
    1. Drive from Des Moines to Saint Charlescar car 293.4 mi
    4h 59m
    $54–78

  3. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus Greyhound US0157S
    2. Take the train from Galesburg Amtrak Station to Naperville Amtrak Stationtrain train Carl Sandburg / ...
    8h 16m
    $121–209

  4. Fly to Chicago Midway International Airport, train

    1. Fly from Des Moines (DSM) to Chicago Midway International Airport (MDW)plane plane DSM - MDW
    2. Take the train from Chicago OTC to Genevatrain train
    4h 11m
    $107–498

  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago OTC to Genevatrain train Up-W
    9h 35m
    $70–120

Des Moines (DSM) to Chicago O'Hare International Airport (ORD) flights

Calendar70Weekly Planes
Duration1h 55mAverage Duration
Ticket$59Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Saint Charles.ExpandLaunch map view
  • Distance: 342.7 mi
  • Duration: 3h 34m

What companies run services between Des Moines, IA, USA and Saint Charles, IL, USA?

There is no direct connection from Des Moines to Saint Charles. However, you can take the taxi to Des-Moines-Airport-DSM airport, fly to Chicago O'Hare International Airport (ORD), walk to O'Hare, take the subway to Rosemont, walk to Rosemont CTA Station, take the bus to Elgin Transportation Center Bay 4, then take the taxi to Saint Charles. Alternatively, you can take a bus from Des Moines to Saint Charles via Galesburg, Galesburg Amtrak Station, and Naperville Amtrak Station in around 8h 16m.

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