Rome2Rio

How to get fromDes Moines to Sanibel Islandby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Sanibel Island

See all options

There are 5 ways to get from Des Moines to Sanibel Island by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Ft. Myers (RSW)plane plane DSM - RSW
    3h 46m
    $273–961

  2. Drive 1,441.9 mi

    cheapest
    1. Drive from Des Moines to Sanibel Islandcar car 1,441.9 mi
    26h 31m
    $264–381

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    4. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    36h 23m
    $290–517

  4. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Tampatrain train
    3. Take the bus from Tampa to Fort Myers Amtrak Bus Stopbus bus
    2d 6h
    $716–1,451

  5. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Tampatrain train
    4. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    2d 7h
    $711–1,483

Des Moines (DSM) to Ft. Myers (RSW) flights

Calendar51Weekly Planes
Duration5h 35mAverage Duration
Ticket$186Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Sanibel Island.ExpandLaunch map view
  • Distance: 1,268.2 mi
  • Duration: 3h 46m

What companies run services between Des Moines, IA, USA and Sanibel Island, FL, USA?

Allegiant Air, Southwest Airlines, and two other airlines fly from Des Moines (DSM) to Ft. Myers (RSW) every 4 hours. Alternatively, you can take a bus from Des Moines to Sanibel Island via St Louis Bus Station, Atlanta Bus Station, Tampa Bus Station, Rosa Parks Transportation Ctr, and Cape Coral Transfer Center in around 36h 23m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers