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How to get fromDes Moines to Santa Anaby plane, bus (Greyhound), bus, train, or car

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There are 5 ways to get from Des Moines to Santa Ana by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to John Wayne Airport Orange County

    best
    1. Fly from Des Moines (DSM) to John Wayne Airport Orange County (SNA)plane plane DSM - SNA
    4h 4m
    $287–1,156

  2. Fly to Los Angeles International Airport, train

    cheapest
    1. Fly from Des Moines (DSM) to Los Angeles International Airport (LAX)plane plane DSM - LAX
    2. Take the train from Los Angeles to Santa Anatrain train
    6h 50m
    $176–707

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to Las Vegas Bus Terminalbus bus
    3. Take the bus from Las Vegas Bus Terminal to Santa Ana Bus Stopbus bus
    37h 25m
    $269–513

  4. Bus, train

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson 803 / ...
    2. Take the train from Kansas City to Fullerton Amtrak Stationtrain train Southwest Chief
    41h 9m
    $607–1,277

  5. Drive 1,680 mi

    1. Drive from Des Moines to Santa Anacar car 1,680 mi
    26h 2m
    $307–443

Des Moines to Santa Ana by bus (Greyhound)

Calendar7Weekly Buses
Duration37h 25mAverage Duration
Ticket$269Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Santa Ana.ExpandLaunch map view
  • Distance: 1,438.7 mi
  • Duration: 4h 4m

What companies run services between Des Moines, IA, USA and Santa Ana, CA, USA?

Allegiant Air, Southwest Airlines, and three other airlines fly from Des Moines (DSM) to John Wayne Airport Orange County (SNA) every 4 hours. Alternatively, you can take a bus from Des Moines to Santa Ana Bus Stop via Denver Union Station and Las Vegas Bus Terminal in around 37h 25m.

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Need to know: Greyhound

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