There are 6 ways to get from Des Moines to Santa Fe by plane, bus, train, bus (Greyhound, Flixbus), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Des Moines to Santa Fe Municipal Airport
best- Fly from Des Moines (DSM) to Santa Fe Municipal Airport (SAF)plane DSM - SAF
5h 2m$169–697Drive to Fort Dodge Municipal Airport, fly to Santa Fe Municipal Airport
cheapest- Drive from Des Moines to Fort Dodge Municipal Airport (FOD)car
- Fly from Fort Dodge Municipal Airport (FOD) to Santa Fe Municipal Airport (SAF)plane FOD - SAF
12h 55m$123–470Bus, train
- Take the bus from Des Moines to Kansas City Bus Stationbus Greyhound US0156
- Take the train from Kansas City to Lamy Stationtrain Southwest Chief
22h 35m$295–614Bus
- Take the bus from Des Moines to Denver Union Stationbus
- Take the bus from Denver Union Station to Pueblo Transitbus
- Take the bus from Pueblo, CO to Santa Febus
22h 41m$191–322Drive 944 mi
- Drive from Des Moines to Santa Fecar 944 mi
16h 3m$173–249Fly Des Moines to Albuquerque International Airport, train
- Fly from Des Moines (DSM) to Albuquerque International Airport (ABQ)plane DSM - ABQ
- Take the train from Downtown Albuquerque Rail Runner Station to Santa Fe Depot Rail Runner Stationtrain
8h 1m$204–931
Des Moines to Santa Fe by bus, foot, and train
Questions & Answers
The cheapest way to get from Des Moines to Santa Fe is to drive which costs $170 - $250 and takes 16h 3m.
The fastest way to get from Des Moines to Santa Fe is to fly which takes 5h 2m and costs $160 - $700.
No, there is no direct bus from Des Moines to Santa Fe. However, there are services departing from Des Moines and arriving at Santa Fe via Denver Union Station and Pueblo, CO. The journey, including transfers, takes approximately 22h 41m.
The distance between Des Moines and Santa Fe is 807 miles. The road distance is 949.5 miles.
The best way to get from Des Moines to Santa Fe without a car is to bus and train which takes 22h 35m and costs $290 - $650.
It takes approximately 5h 2m to get from Des Moines to Santa Fe, including transfers.
Des Moines to Santa Fe bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to Santa Fe is to fly which takes 5h 2m and costs $160 - $700. Alternatively, you can bus, which costs $190 - $330 and takes 22h 41m.
Des Moines to Santa Fe bus services, operated by Greyhound USA, arrive at Denver Union Station.
Santa Fe is 1h behind Des Moines. It is currently 6:37 AM in Des Moines and 5:37 AM in Santa Fe.
What companies run services between Des Moines, IA, USA and Santa Fe, NM, USA?
United Airlines and American Airlines fly from Des Moines (DSM) to Santa Fe Municipal Airport (SAF) every 4 hours. Alternatively, you can take a bus from Des Moines to Santa Fe via Denver Union Station, Pueblo, CO, and Santa Fe in around 22h 41m.
- Website
- aa.com
Flights from Des Moines to Santa Fe Municipal Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 5m
- When
- Every day
- Estimated price
- $160–750
Flights from Des Moines to Santa Fe Municipal Airport via Chicago O'Hare
- Ave. Duration
- 8h 36m
- When
- Every day
- Estimated price
- $180–800
Flights from Fort Dodge Municipal Airport to Santa Fe Municipal Airport via Chicago O'Hare
- Ave. Duration
- 11h 34m
- When
- Every day
- Estimated price
- $120–550
Flights from Des Moines to Albuquerque International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 41m
- When
- Every day
- Estimated price
- $220–1,000
Flights from Des Moines to Albuquerque International Airport via Phoenix
- Ave. Duration
- 6h 55m
- When
- Every day
- Estimated price
- $260–1,200
- Website
- united.com
Flights from Des Moines to Santa Fe Municipal Airport via Denver
- Ave. Duration
- 4h 43m
- When
- Every day
- Estimated price
- $130–650
Flights from Fort Dodge Municipal Airport to Santa Fe Municipal Airport via Denver
- Ave. Duration
- 16h 19m
- When
- Every day
- Estimated price
- $85–420
Flights from Fort Dodge Municipal Airport to Santa Fe Municipal Airport via Chicago O'Hare, Denver
- Ave. Duration
- 10h 41m
- When
- Every day
- Estimated price
- $130–550
Flights from Des Moines to Albuquerque International Airport via Denver
- Ave. Duration
- 4h 40m
- When
- Every day
- Estimated price
- $180–900
- Website
- southwest.com
Flights from Des Moines to Albuquerque International Airport via Denver
- Ave. Duration
- 4h 6m
- When
- Sunday, Tuesday, Wednesday, and Saturday
- Estimated price
- $180–900
Flights from Des Moines to Albuquerque International Airport via Chicago Midway
- Ave. Duration
- 7h 50m
- When
- Tuesday, Wednesday, Sunday, and Saturday
- Estimated price
- $250–1,100
Flights from Des Moines to Albuquerque International Airport via Phoenix
- Ave. Duration
- 8h 40m
- When
- Sunday
- Estimated price
- $260–1,200
- Website
- delta.com
Flights from Des Moines to Albuquerque International Airport via Minneapolis
- Ave. Duration
- 6h 55m
- When
- Every day
- Estimated price
- $220–1,000
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Kansas City to Lamy Station
- Ave. Duration
- 16h 2m
- Frequency
- Once daily
- Estimated price
- $260–550
- Website
- Amtrak
- Phone
- 1-866-795-7245
- [email protected]
- Website
- Rio Metro Regional Transit District
Train from Downtown Albuquerque Rail Runner Station to Santa Fe Depot Rail Runner Station
- Ave. Duration
- 1h 44m
- Frequency
- Every 3 hours
- Estimated price
- $6–9
- Website
- Rio Metro Regional Transit District
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to Kansas City Bus Station
- Ave. Duration
- 3h 15m
- Frequency
- Twice daily
- Estimated price
- $29–60
- Website
- Greyhound
Bus from Des Moines to Denver Union Station
- Ave. Duration
- 14h 25m
- Frequency
- Twice daily
- Estimated price
- $100–200
- Website
- Greyhound
Bus from Denver Union Station to Pueblo Transit
- Ave. Duration
- 2h 10m
- Frequency
- 3 times a day
- Estimated price
- $17–35
- Website
- Greyhound
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Denver Union Station to Pueblo Transit
- Ave. Duration
- 2h 25m
- Frequency
- Twice daily
- Estimated price
- $18–30
- Schedules at
- Flixbus USA
- Phone
- +1 800-923-1799
- [email protected]
- Website
- Omnibus Express
Bus from Pueblo, CO to Santa Fe
- Ave. Duration
- 4h
- Frequency
- Once daily
- Estimated price
- $65–85
- Schedules at
- Omnibus Express
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More Questions & Answers
Yes, the driving distance between Des Moines to Santa Fe is 950 miles. It takes approximately 16h 3m to drive from Des Moines to Santa Fe.
There are 246+ hotels available in Santa Fe.











