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How to get fromDes Moines to Seymourby bus (Greyhound), bus, train, car, or plane

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There are 6 ways to get from Des Moines to Seymour by bus (Greyhound), bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus Greyhound US0157S
    2. Take the bus from Indianapolis to TA Travel Center - Seymourbus bus Indianapolis
    13h 17m
    $101–164

  2. Drive  528.2 mi

    cheapest
    1. Drive from Des Moines to Seymourcar car 528.2 mi
    8h 54m
    $97–140

  3. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Indianapolistrain train
    4. Take the bus from Indianapolis to TA Travel Center - Seymourbus bus
    17h 56m
    $150–316

  4. Fly to Indianapolis, bus

    1. Fly from Des Moines (DSM) to Indianapolis (IND)plane plane DSM - IND
    2. Take the bus from Indianapolis to TA Travel Center - Seymourbus bus
    8h 31m
    $148–723

  5. Fly to Louisville International Airport, bus

    1. Fly from Des Moines (DSM) to Louisville International Airport (SDF)plane plane DSM - SDF
    2. Take the bus from El Mercadito Grocery - Clarksville, IN to TA Travel Center - Seymourbus bus
    7h 52m
    $181–870

  6. Fly to Nashville, bus

    1. Fly from Des Moines (DSM) to Nashville (BNA)plane plane DSM - BNA
    2. Take the bus from Tornado Bus Co - Nashville to TA Travel Center - Seymourbus bus
    8h 16m
    $168–658

Des Moines (DSM) to Indianapolis (IND) flights

Calendar128Weekly Planes
Duration5h 23mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Seymour.ExpandLaunch map view
  • Distance: 544.4 mi
  • Duration: 13h 17m

What companies run services between Des Moines, IA, USA and Seymour, IN, USA?

You can take a bus from Des Moines to Seymour via Indianapolis Union Station, Ctc-R, Lafayette Rd & Georgetown Rd, Indianapolis, and TA Travel Center - Seymour in around 13h 17m.

Airlines
Train operators
Bus operators

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