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How to get fromDes Moines to Siesta Keyby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to Siesta Key

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There are 5 ways to get from Des Moines to Siesta Key by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Sarasota–Bradenton International Airport (SRQ)plane plane DSM - SRQ
    3h 58m
    $121–517

  2. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Tampa Bus Stationbus bus
    4. Take the bus from Tampa Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    36h 41m
    $270–420

  3. Bus, train, drive

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Tampatrain train
    4. Drive from Tampa to Siesta Keycar car
    2d 3h
    $1,082–1,811

  4. Drive  1,378.7 mi

    1. Drive from Des Moines to Siesta Keycar car 1,378.7 mi
    24h 38m
    $252–364

  5. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Winter Park Amtrak Stationtrain train
    3. Take the bus from Orlando Bus Station to Sarasota Cattlemen Transfer Centerbus bus
    2d 4h
    $1,004–1,649

Des Moines to Siesta Key by bus

Calendar5Weekly Buses
Duration36h 41mAverage Duration
Ticket$270Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Des Moines to Siesta Key.ExpandLaunch map view
  • Distance: 1,183.2 mi
  • Duration: 3h 58m

What companies run services between Des Moines, IA, USA and Siesta Key, FL, USA?

Allegiant Air, Southwest Airlines, and Delta fly from Des Moines (DSM) to Sarasota–Bradenton International Airport (SRQ) 3 times a day. Alternatively, you can take a bus from Des Moines to Ocean Blvd @ Avenida Madera via Indianapolis Union Station, Atlanta Bus Station, Tampa Bus Station, Sarasota Cattlemen Transfer Center, and Cattlemen Transit Station in around 36h 41m.

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