Rome2Rio

How to get fromDes Moines to Sikestonby plane, car, bus, train, taxi, or bus (Greyhound)

Find Transport to Sikeston

See all options

There are 7 ways to get from Des Moines to Sikeston by plane, car, bus, train, taxi, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Barkley Regional Airport, drive

    best
    1. Fly from Des Moines (DSM) to Barkley Regional Airport (PAH)plane plane DSM - PAH
    2. Drive from Barkley Regional Airport (PAH) to Sikestoncar car
    6h 40m
    $113–516

  2. Drive  458.5 mi

    cheapest
    1. Drive from Des Moines to Sikestoncar car 458.5 mi
    8h 46m
    $84–121

  3. Bus, train, taxi

    1. Take the bus from Des Moines to Bloomington-Normalbus bus
    2. Take the train from Bloomington-Normal to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    4. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    13h 45m
    $187–322

  4. Fly to Williamson County Regional Airport, bus

    1. Fly from Des Moines (DSM) to Williamson County Regional Airport (MWA)plane plane DSM - MWA
    2. Take the bus from Marathon Gas Station - Marion to Flying J - Matthewsbus bus
    6h 58m
    $158–592

  5. Bus

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus Greyhound US0157S
    2. Take the bus from Road Ranger Truck Stop - Champaign to Flying J - Matthewsbus bus Milwaukee
    13h 48m
    $147–223

  6. Bus, train, taxi via Kansas City

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    4. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    14h 16m
    $204–372

  7. Bus, taxi

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    4. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    5. Take the taxi from Cape Girardeau to Sikestontaxi taxi
    14h 26m
    $185–279

Des Moines (DSM) to Barkley Regional Airport (PAH) flights

Calendar26Weekly Planes
Duration6h 18mAverage Duration
Ticket$87Cheapest Price
See schedules

Questions & Answers

Map of how to get from Des Moines to Sikeston.ExpandLaunch map view
  • Distance: 466.2 mi
  • Duration: 6h 40m

What companies run services between Des Moines, IA, USA and Sikeston, MO, USA?

You can take a bus from Des Moines to Sikeston via Champaign Intermodal Trans Ctr, Road Ranger Truck Stop - Champaign, and Flying J - Matthews in around 13h 48m.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound