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How to get fromDes Moines to South Carolinaby plane, taxi, bus, train, or car

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There are 7 ways to get from Des Moines to South Carolina by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Charlotte Douglas International Airport, taxi

    best
    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 7m
    $278–1,071

  2. Fly to Charleston International Airport

    cheapest
    1. Fly from Des Moines (DSM) to Charleston International Airport (CHS)plane plane DSM - CHS
    5h 40m
    $170–773

  3. Bus, train

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    38h 4m
    $512–1,060

  4. Drive 1,158.9 mi

    1. Drive from Des Moines to Charlestoncar car 1,158.9 mi
    20h 40m
    $212–306

  5. Fly to Greenville–Spartanburg International Airport

    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    4h 30m
    $243–1,016

  6. Fly to Columbia

    1. Fly from Des Moines (DSM) to Columbia (CAE)plane plane DSM - CAE
    6h
    $360–1,723

  7. Bus, train, taxi, drive

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Savannah Stationtrain train
    3. Take the taxi from Savannah Station to Trolley Stop 10 - Coligny Beach Parktaxi taxi
    4. Drive from Trolley Stop 1 - Shelter Cove Towne Centre to Charlestoncar car
    44h 15m
    $680–1,275

Des Moines (DSM) to Charlotte Douglas International Airport (CLT) flights

Calendar74Weekly Planes
Duration4h 14mAverage Duration
Ticket$188Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to South Carolina.ExpandLaunch map view
  • Distance: 848.1 mi
  • Duration: 3h 7m

What companies run services between Des Moines, IA, USA and South Carolina, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) every 2 hours.

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