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How to get fromDes Moines to Spartanburgby plane, bus (Greyhound), bus, train, or car

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There are 9 ways to get from Des Moines to Spartanburg by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    4h 40m
    $184–693

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    5h 41m
    $108–457

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Spartanburgbus bus
    25h 55m
    $223–340

  4. Bus, train via Charlottesville

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Spartanburg Stationtrain train
    34h 14m
    $595–964

  5. Drive  959 mi

    1. Drive from Des Moines to Spartanburgcar car 959 mi
    17h 27m
    $164–237

  6. Fly to Charlotte Douglas International Airport, train

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    6h 3m
    $183–744

  7. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbusbus bus
    3. Take the bus from Columbus to Charlottebus bus
    4. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    29h 54m
    $179–342

  8. Bus, train via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to Charlotte Amtrak Stationtrain train
    4. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    39h 4m
    $742–1,246

  9. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Charlotte Amtrak Stationtrain train
    5. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    40h 2m
    $808–1,361

Des Moines to Spartanburg by bus and train

Calendar3Weekly Services
Duration34h 14mAverage Duration
Ticket$595Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Des Moines to Spartanburg.ExpandLaunch map view
  • Distance: 796.8 mi
  • Duration: 4h 40m

What companies run services between Des Moines, IA, USA and Spartanburg, SC, USA?

Delta, American Airlines, and two other airlines fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a bus from Des Moines to Spartanburg via Indianapolis Union Station, Atlanta Bus Station, and Spartanburg in around 25h 55m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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