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How to get fromDes Moines to Spartanburgby plane, bus (Greyhound, Flixbus), bus, train, or car

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There are 6 ways to get from Des Moines to Spartanburg by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP)plane plane DSM - GSP
    4h 34m
    $273–1,091

  2. Fly to Asheville Regional Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Asheville Regional Airport (AVL)plane plane DSM - AVL
    2. Drive from Asheville-Airport-AVL to Spartanburgcar car
    5h 12m
    $157–686

  3. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Spartanburgbus bus
    23h 54m

  4. Bus, train

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Spartanburg Stationtrain train
    34h 19m

  5. Drive 959 mi

    1. Drive from Des Moines to Spartanburgcar car 959 mi
    17h 26m
    $175–253

  6. Fly to Charlotte Douglas International Airport, train

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the train from Charlotte Amtrak Station to Spartanburg Stationtrain train
    6h 10m
    $237–1,027

Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) flights

Calendar79Weekly Planes
Duration5h 33mAverage Duration
Ticket$206Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Spartanburg.ExpandLaunch map view
  • Distance: 796.8 mi
  • Duration: 4h 34m

What companies run services between Des Moines, IA, USA and Spartanburg, SC, USA?

Delta, American Airlines, and United Airlines fly from Des Moines (DSM) to Greenville–Spartanburg International Airport (GSP) every 2 hours. Alternatively, you can take a bus from Des Moines to Spartanburg via St Louis Bus Station, Atlanta Bus Station, and Spartanburg in around 23h 54m.

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