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How to get fromDes Moines to St. Louisby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Amtrak, Flixbus)

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There are 6 ways to get from Des Moines to St. Louis by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Amtrak, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL)plane plane DSM - STL
    4h 58m
    $121–674

  2. Drive  329.8 mi

    cheapest
    1. Drive from Des Moines to St. Louiscar car 329.8 mi
    6h 39m
    $61–87

  3. Bus via Kansas City

    1. Take the bus from Des Moines to Kansas Citybus bus Jefferson Lines 803 / ...
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    8h 30m
    $88–142

  4. Bus, train via Kansas City

    1. Take the bus from Des Moines to Kansas City Bus Stationbus bus Greyhound US0156
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    10h 36m
    $98–222

  5. Bus, train

    1. Take the bus from Des Moines to Bloomington-Normalbus bus Greyhound US0157S
    2. Take the train from Bloomington-Normal to St. Louistrain train Lincoln Service / ...
    10h 5m
    $81–172

  6. Bus

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to St Louis Bus Stationbus bus
    10h 46m
    $79–129

Des Moines to St. Louis by bus

Calendar18Weekly Buses
Duration8h 30mAverage Duration
Ticket$88Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to St. Louis.ExpandLaunch map view
  • Distance: 280 mi
  • Duration: 4h 58m

What companies run services between Des Moines, IA, USA and St. Louis, MO, USA?

United Airlines, Delta, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from Des Moines to St Louis Bus Station via Kansas City and Kansas City Bus Station in around 8h 30m.

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Need to know: Greyhound

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