There are 3 ways to get from Des Moines to St. Louis by plane, bus (Greyhound), or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Des Moines to St. Louis by bus (Greyhound)
Questions & Answers
The cheapest way to get from Des Moines to St. Louis is to bus which costs $60 - $120 and takes 8h 20m.
The fastest way to get from Des Moines to St. Louis is to fly which takes 4h 43m and costs $130 - $700.
Yes, there is a direct bus departing from Des Moines and arriving at St Louis Bus Station station. Services depart once daily, and operate every day. The journey takes approximately 8h 20m.
The distance between Des Moines and St. Louis is 282 miles. The road distance is 331.7 miles.
The best way to get from Des Moines to St. Louis without a car is to bus which takes 8h 20m and costs $60 - $120.
It takes approximately 4h 43m to get from Des Moines to St. Louis, including transfers.
Des Moines to St. Louis bus services, operated by Greyhound USA, depart from Des Moines station.
The best way to get from Des Moines to St. Louis is to fly which takes 4h 43m and costs $130 - $700. Alternatively, you can bus, which costs $60 - $120 and takes 8h 20m.
Des Moines to St. Louis bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Des Moines to St. Louis is 332 miles. It takes approximately 6h 39m to drive from Des Moines to St. Louis.
What companies run services between Des Moines, IA, USA and St. Louis, MO, USA?
Delta, United Airlines, and two other airlines fly from Des Moines (DSM) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Greyhound USA operates a bus from Des Moines to St Louis Bus Station once daily. Tickets cost $60–120 and the journey takes 8h 20m.
- Website
- aa.com
Flights from Des Moines to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 28m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 5h 40m
- When
- Every day
- Estimated price
- $190–850
- Website
- delta.com
Flights from Des Moines to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 4h 45m
- When
- Every day
- Estimated price
- $130–700
Flights from Des Moines to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 5h 39m
- When
- Every day
- Estimated price
- $190–900
Flights from Des Moines to Lambert–St. Louis International Airport via Detroit
- Ave. Duration
- 6h 15m
- When
- Every day
- Estimated price
- $160–800
- Website
- united.com
Flights from Des Moines to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 58m
- When
- Every day
- Estimated price
- $110–650
Flights from Des Moines to Lambert–St. Louis International Airport via Denver
- Ave. Duration
- 6h 19m
- When
- Every day
- Estimated price
- $210–950
- Website
- southwest.com
Flights from Des Moines to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 5h 15m
- When
- Monday, Thursday, Friday, Tuesday, Wednesday, and Sunday
- Estimated price
- $110–650
Flights from Des Moines to Lambert–St. Louis International Airport via Denver
- Ave. Duration
- 5h 30m
- When
- Sunday
- Estimated price
- $210–950
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Des Moines to St Louis Bus Station
- Ave. Duration
- 8h 20m
- Frequency
- Once daily
- Estimated price
- $60–120
- Website
- Greyhound
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