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How to get fromDes Moines to St. Marysby plane, taxi, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Des Moines to St. Marys by plane, taxi, bus (Greyhound, Amtrak, Flixbus), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Jacksonville, taxi

    best
    1. Fly from Des Moines (DSM) to Jacksonville (JAX)plane plane DSM - JAX
    2. Take the taxi from Jacksonville-Airport-JAX to St. Marystaxi taxi
    5h 30m
    $258–871

  2. Drive 1,165.2 mi

    cheapest
    1. Drive from Des Moines to St. Maryscar car 1,165.2 mi
    22h 3m
    $213–308

  3. Bus via Carbondale

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St. Louis to Carbondalebus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Kingslandbus bus
    30h 7m
    $239–449

  4. Bus, train, taxi

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Jacksonvilletrain train
    4. Take the taxi from Jacksonville to St. Marystaxi taxi
    45h 2m
    $684–1,403

  5. Fly to Brunswick Golden Isles Airport, taxi

    1. Fly from Des Moines (DSM) to Brunswick Golden Isles Airport (BQK)plane plane DSM - BQK
    2. Take the taxi from Brunswick Golden Isles Airport (BQK) to St. Marystaxi taxi
    5h 36m
    $278–871

  6. Bus

    1. Take the bus from Des Moines to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Kingslandbus bus
    30h 42m
    $244–459

  7. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Jacksonvilletrain train
    3. Take the bus from JRTC - Express Select to Yulee Park & Ridebus bus
    46h 24m
    $612–1,283

Des Moines (DSM) to Jacksonville (JAX) flights

Calendar87Weekly Planes
Duration6h 5mAverage Duration
Ticket$164Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to St. Marys.ExpandLaunch map view
  • Distance: 1,049.1 mi
  • Duration: 5h 30m

What companies run services between Des Moines, IA, USA and St. Marys, GA, USA?

You can take a bus from Des Moines to St. Marys via St Louis Bus Station, St. Louis, Carbondale Intermodal Station, Atlanta Bus Station, and Kingsland in around 30h 7m.

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