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How to get fromDes Moines to Syracuseby plane, bus, train, bus (Greyhound), or car

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There are 7 ways to get from Des Moines to Syracuse by plane, bus, train, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Syracuse Hancock International Airport

    best
    1. Fly from Des Moines (DSM) to Syracuse Hancock International Airport (SYR)plane plane DSM - SYR
    6h 21m
    $259–1,229

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Syracuse Bus Stationbus bus
    23h 5m
    $150–305

  3. Bus, train

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123S / ...
    2. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train Lake Shore Limited
    21h 12m
    $260–535

  4. Drive 992 mi

    1. Drive from Des Moines to Syracusecar car 992 mi
    16h 46m
    $181–262

  5. Fly to Rochester, train

    1. Fly from Des Moines (DSM) to Rochester (ROC)plane plane DSM - ROC
    2. Take the train from Rochester to Syracuse Regional Transportation Centertrain train
    6h 42m
    $267–1,313

  6. Fly to Greater Binghamton Airport, bus

    1. Fly from Des Moines (DSM) to Greater Binghamton Airport (BGM)plane plane DSM - BGM
    2. Take the bus from Binghamton to Syracuse Bus Stationbus bus
    8h 40m
    $202–761

  7. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Syracuse Regional Transportation Centertrain train
    22h 23m
    $291–609

Des Moines to Syracuse by bus, foot, and train

Calendar14Weekly Services
Duration21h 12mAverage Duration
Ticket$260Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Syracuse.ExpandLaunch map view
  • Distance: 919.5 mi
  • Duration: 6h 21m

What companies run services between Des Moines, IA, USA and Syracuse, NY, USA?

Allegiant Air, Delta, and two other airlines fly from Des Moines (DSM) to Syracuse Hancock International Airport (SYR) every 2 hours. Alternatively, you can take a bus from Des Moines to Syracuse Bus Station via Chicago Bus Station and Cleveland Bus Station in around 23h 5m.

Airlines
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