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How to get fromDes Moines to Tallahasseeby plane, bus (Greyhound, Amtrak), car, bus, train, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Des Moines to Tallahassee by plane, bus (Greyhound, Amtrak), car, bus, train, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tallahassee

    best
    1. Fly from Des Moines (DSM) to Tallahassee (TLH)plane plane DSM - TLH
    4h 56m
    $191–850

  2. Fly to Valdosta, drive

    cheapest
    1. Fly from Des Moines (DSM) to Valdosta (VLD)plane plane DSM - VLD
    2. Drive from Valdosta (VLD) to Tallahasseecar car
    7h 15m
    $142–643

  3. Bus

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville Bus Station to Tallahasseebus bus
    25h 55m
    $194–294

  4. Drive  1,082.5 mi

    1. Drive from Des Moines to Tallahasseecar car 1,082.5 mi
    20h 8m
    $198–286

  5. Fly to Dothan Regional Airport, drive

    1. Fly from Des Moines (DSM) to Dothan Regional Airport (DHN)plane plane DSM - DHN
    2. Drive from Dothan Regional Airport (DHN) to Tallahasseecar car
    7h 6m
    $147–650

  6. Fly to Northwest Florida Beaches International Airport, drive

    1. Fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP)plane plane DSM - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Tallahasseecar car
    6h 20m
    $157–650

  7. Bus, train

    1. Take the bus from Des Moines to Champaign Intermodal Trans Ctrbus bus
    2. Take the train from Champaign-Urbana to Carbondaletrain train
    3. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Tallahasseebus bus
    26h 14m
    $205–365

  8. Bus via Atlanta

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Bloomington, INbus bus
    3. Take the bus from Bloomington to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    29h 30m
    $209–364

Des Moines to Tallahassee by bus

Calendar7Weekly Buses
Duration25h 55mAverage Duration
Ticket$194Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Tallahassee.ExpandLaunch map view
  • Distance: 940.5 mi
  • Duration: 4h 56m

What companies run services between Des Moines, IA, USA and Tallahassee, FL, USA?

Delta and American Airlines fly from Des Moines (DSM) to Tallahassee (TLH) every 4 hours. Alternatively, you can take a bus from Des Moines to Tallahassee via Indianapolis Union Station and Nashville Bus Station in around 25h 55m.

Airlines
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