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How to get fromDes Moines to Tallahasseeby plane, bus, train, car, bus (Greyhound), or bus (Amtrak, Flixbus, Greyhound)

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There are 7 ways to get from Des Moines to Tallahassee by plane, bus, train, car, bus (Greyhound), or bus (Amtrak, Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Tallahassee

    best
    1. Fly from Des Moines (DSM) to Tallahassee (TLH)plane plane DSM - TLH
    4h 48m
    $220–898

  2. Fly to Dothan Regional Airport, drive

    cheapest
    1. Fly from Des Moines (DSM) to Dothan Regional Airport (DHN)plane plane DSM - DHN
    2. Drive from Dothan Regional Airport (DHN) to Tallahasseecar car
    6h 54m
    $176–748

  3. Bus, train

    1. Take the bus from Des Moines to Champaignbus bus
    2. Take the train from Champaign-Urbana to Carbondaletrain train
    3. Take the bus from Carbondale Intermodal Station to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Tallahasseebus bus
    26h 24m

  4. Drive 1,082.5 mi

    1. Drive from Des Moines to Tallahasseecar car 1,082.5 mi
    20h 8m
    $198–286

  5. Fly to Northwest Florida Beaches International Airport, drive

    1. Fly from Des Moines (DSM) to Northwest Florida Beaches International Airport (ECP)plane plane DSM - ECP
    2. Drive from Northwest Florida Beaches International Airport (ECP) to Tallahasseecar car
    6h 20m
    $176–748

  6. Bus

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the bus from Indianapolis Union Station to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Tallahasseebus bus
    28h 40m

  7. Bus via Springfield

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the bus from Galesburg Amtrak Station to Springfieldbus bus
    3. Take the bus from Springfield SMTD Transfer Center to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    28h 51m

Des Moines (DSM) to Tallahassee (TLH) flights

Calendar50Weekly Planes
Duration6h 2mAverage Duration
Ticket$179Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Tallahassee.ExpandLaunch map view
  • Distance: 940.5 mi
  • Duration: 4h 48m

What companies run services between Des Moines, IA, USA and Tallahassee, FL, USA?

Delta and American Airlines fly from Des Moines (DSM) to Tallahassee (TLH) every 4 hours. Alternatively, you can take a bus from Des Moines to Tallahassee via Indianapolis Union Station and Montgomery Intermodal Center in around 28h 40m.

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