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How to get fromDes Moines to West Lafayetteby plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)

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There are 8 ways to get from Des Moines to West Lafayette by plane, bus (Flixbus, Greyhound), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Purdue University Airport

    best
    1. Fly from Des Moines (DSM) to Purdue University Airport (LAF)plane plane DSM - LAF
    5h 24m
    $104–522

  2. Bus via Des Moines

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus Greyhound US0123 / ...
    2. Take the bus from Chicago Train Station to Lafayette Bus Stopbus bus Greyhound US0100
    10h 32m
    $69–132

  3. Bus

    1. Take the bus from Des Moines to Chicagobus bus Btw 1202 / ...
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus FlixBus 2511 / ...
    9h 4m

  4. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train
    12h 26m

  5. Drive 408 mi

    1. Drive from Des Moines to West Lafayettecar car 408 mi
    7h 38m
    $75–108

  6. Fly to Indianapolis, bus

    1. Fly from Des Moines (DSM) to Indianapolis (IND)plane plane DSM - IND
    2. Take the bus from Indianapolis Airport to Purdue Memorial Unionbus bus
    6h 13m
    $176–811

  7. Fly to Chicago O'Hare International Airport, bus

    1. Fly from Des Moines (DSM) to Chicago O'Hare International Airport (ORD)plane plane DSM - ORD
    2. Take the bus from Chicago Bus Station to Lafayette Bus Stopbus bus
    5h 40m
    $98–441

  8. Bus, train

    1. Take the bus from Des Moines to Chicagobus bus Btw 1202 / ...
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    10h 20m

Des Moines (DSM) to Purdue University Airport (LAF) flights

Calendar33Weekly Planes
Duration6h 36mAverage Duration
Ticket$87Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to West Lafayette.ExpandLaunch map view
  • Distance: 367.1 mi
  • Duration: 5h 24m

What companies run services between Des Moines, IA, USA and West Lafayette, IN, USA?

United Airlines and American Airlines fly from Des Moines (DSM) to Purdue University Airport (LAF) 5 times a day. Alternatively, you can take a bus from Des Moines to Lafayette Bus Stop via Chicago Bus Station in around 9h 4m.

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