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How to get fromDes Moines to Winston-Salemby plane, bus, train, or car

Find Transport to Winston-Salem

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There are 4 ways to get from Des Moines to Winston-Salem by plane, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO)plane plane DSM - GSO
    5h 36m
    $267–1,144

  2. Drive 976.3 mi

    cheapest
    1. Drive from Des Moines to Winston-Salemcar car 976.3 mi
    16h 56m
    $179–258

  3. Bus, train

    1. Take the bus from Des Moines to Indianapolisbus bus
    2. Take the train from Indianapolis to Ashland Amtrak Stationtrain train
    3. Take the bus from Ashland Bus Station to Winston Salem(Trans Center)bus bus
    25h 5m

  4. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    5h 46m
    $219–1,017

Des Moines (DSM) to Piedmont Triad International Airport (GSO) flights

Calendar86Weekly Planes
Duration5h 51mAverage Duration
Ticket$230Cheapest Price
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Questions & Answers

Map of how to get from Des Moines to Winston-Salem.ExpandLaunch map view
  • Distance: 856.6 mi
  • Duration: 5h 36m

What companies run services between Des Moines, IA, USA and Winston-Salem, NC, USA?

American Airlines, Delta, and United Airlines fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO) every 2 hours.

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