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How to get fromDes Moines to Winston-Salemby plane, bus (Greyhound), bus, train, or car

Find Transport to Winston-Salem

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There are 8 ways to get from Des Moines to Winston-Salem by plane, bus (Greyhound), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Piedmont Triad International Airport

    best
    1. Fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO)plane plane DSM - GSO
    5h 38m
    $298–1,446

  2. Bus via Chicago

    cheapest
    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the bus from Chicago to Columbusbus bus
    3. Take the bus from Wilson & Ferrell Shell Station - Columbus to Winston Salem(Trans Center)bus bus
    26h 20m
    $150–269

  3. Bus (Greyhound)

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Columbusbus bus
    3. Take the bus from Columbus to Winston Salem(Trans Center)bus bus
    25h 50m
    $170–277

  4. Bus, train

    1. Take the bus from Des Moines to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Charlottesvilletrain train
    3. Take the train from Charlottesville to Greensborotrain train
    4. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    31h 53m
    $505–824

  5. Drive  976.3 mi

    1. Drive from Des Moines to Winston-Salemcar car 976.3 mi
    16h 56m
    $179–258

  6. Fly to Charlotte Douglas International Airport, bus

    1. Fly from Des Moines (DSM) to Charlotte Douglas International Airport (CLT)plane plane DSM - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    5h 41m
    $205–949

  7. Bus, train via Chicago

    1. Take the bus from Des Moines to Chicago Bus Stationbus bus
    2. Take the train from Chicago Union Station to Carytrain train
    3. Take the train from Cary to High Pointtrain train
    37h 2m
    $653–1,114

  8. Bus, train via Galesburg

    1. Take the bus from Des Moines to Galesburgbus bus
    2. Take the train from Galesburg Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    4. Take the train from Raleigh Union Station to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    37h 34m
    $713–1,219

Des Moines to Winston-Salem by bus (Greyhound)

Calendar7Weekly Buses
Duration25h 50mAverage Duration
Ticket$170Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Moines to Winston-Salem.ExpandLaunch map view
  • Distance: 856.6 mi
  • Duration: 5h 38m

What companies run services between Des Moines, IA, USA and Winston-Salem, NC, USA?

Delta, United Airlines, and American Airlines fly from Des Moines (DSM) to Piedmont Triad International Airport (GSO) every 2 hours. Alternatively, you can take a bus from Des Moines to Winston Salem(Trans Center) via Indianapolis Union Station and Columbus in around 25h 50m.

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