There are 5 ways to get from Des Plaines to Des Moines by plane, bus (Greyhound), car, train, or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly from Chicago O'Hare International Airport
best- Fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM)plane ORD - DSM
2h 45m$58–303Bus (Greyhound)
cheapest- Take the bus from Chicago Bus Station to Des Moinesbus Greyhound US0123S / ...
8h 20m$57–93Drive 320.8 mi
- Drive from Des Plaines to Des Moinescar 320.8 mi
5h 43m$59–85Train to Chicago Midway International Airport, fly
- Take the train from Des Plaines to Chicago OTCtrain
- Fly from Chicago Midway International Airport (MDW) to Des Moines (DSM)plane MDW - DSM
4h 9m$79–423Train, bus
- Take the train from Chicago Union Station to Galesburg Amtrak Stationtrain Southwest Chief / ...
- Take the bus from Galesburg to Des Moinesbus Greyhound US0157S
10h 15m$77–158
Des Plaines to Des Moines by train and bus (Greyhound)
Comparing Your Travel Options
The cheapest way to get from Des Plaines to Des Moines is to bus which costs $55 - $95 and takes 8h 20m.
The fastest way to get from Des Plaines to Des Moines is to fly which takes 2h 45m and costs $55 - $310.
No, there is no direct bus from Des Plaines to Des Moines. However, there are services departing from Madison & Canal and arriving at Des Moines via Chicago Bus Station. The journey, including transfers, takes approximately 8h 20m.
The distance between Des Plaines and Des Moines is 309 miles. The road distance is 322.7 miles.
The best way to get from Des Plaines to Des Moines without a car is to bus which takes 8h 20m and costs $55 - $95.
It takes approximately 2h 45m to get from Des Plaines to Des Moines, including transfers.
Des Plaines to Des Moines bus services, operated by Greyhound USA, depart from Chicago Bus Station.
The best way to get from Des Plaines to Des Moines is to fly which takes 2h 45m and costs $55 - $310. Alternatively, you can bus, which costs $55 - $95 and takes 8h 20m.
Des Plaines to Des Moines bus services, operated by Greyhound USA, arrive at Des Moines station.
Yes, the driving distance between Des Plaines to Des Moines is 323 miles. It takes approximately 5h 43m to drive from Des Plaines to Des Moines.
What companies run services between Des Plaines, IL, USA and Des Moines, IA, USA?
American Airlines and United Airlines fly from Chicago O'Hare International Airport (ORD) to Des Moines (DSM) every 3 hours. Alternatively, Greyhound USA operates a bus from Chicago Bus Station to Des Moines 3 times a day. Tickets cost $50–85 and the journey takes 6h 30m.
- Website
- united.com
Flights from Chicago O'Hare International Airport to Des Moines
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- $40–280
- Phone
- +1 312-696-3872
- Website
- Metra
Train from Des Plaines to Chicago OTC
- Ave. Duration
- 39 min
- Frequency
- Hourly
- Estimated price
- $4–5
- Website
- Metra
- Adult
- $4–5
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Chicago Bus Station to Des Moines
- Ave. Duration
- 6h 30m
- Frequency
- 3 times a day
- Estimated price
- $50–85
- Website
- Greyhound
Bus from Galesburg to Des Moines
- Ave. Duration
- 4h 55m
- Frequency
- Once daily
- Estimated price
- $30–55
- Website
- Greyhound
Want to know more about travelling around United States
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Booking & Getting There
There are 251+ hotels available in Des Moines.




