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How to get fromDes Plaines to Louisvilleby plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Amtrak)

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There are 7 ways to get from Des Plaines to Louisville by plane, bus (Greyhound, Amtrak), train, bus, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Louisville International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF)plane plane ORD - SDF
    3h 51m
    $76–493

  2. Fly Chicago O'Hare International Airport to Blue Grass Airport, drive

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Blue Grass Airport (LEX)plane plane ORD - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    3h 53m
    $52–288

  3. Bus via Indianapolis

    1. Take the bus from Chicago Bus Station to Indianapolis Union Stationbus bus Greyhound US0100 / ...
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    7h 50m
    $59–103

  4. Train, bus (Amtrak)

    1. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    2. Take the bus from Indianapolis Union Station to Louisville, KYbus bus Chicago
    9h 33m
    $129–223

  5. Drive  311.3 mi

    1. Drive from Des Plaines to Louisvillecar car 311.3 mi
    5h 28m
    $54–77

  6. Train to Chicago Midway International Airport, fly to Louisville International Airport

    1. Take the train from Des Plaines to Chicago OTCtrain train
    2. Fly from Chicago Midway International Airport (MDW) to Louisville International Airport (SDF)plane plane MDW - SDF
    5h 4m
    $127–813

  7. Bus (Amtrak)

    1. Take the bus from Chicago Union Station to Louisville, KYbus bus Chicago
    9h 44m
    $55–66

Des Plaines to Louisville by train and bus

Calendar14Weekly Services
Duration7h 50mAverage Duration
Ticket$59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Plaines to Louisville.ExpandLaunch map view
  • Distance: 294.7 mi
  • Duration: 3h 51m

What companies run services between Des Plaines, IL, USA and Louisville, KY, USA?

American Airlines and United Airlines fly from Chicago O'Hare International Airport (ORD) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a train from Des Plaines to Louisville, KY via Chicago OTC, Madison & Canal, Harrison & Jefferson, Chicago Bus Station, and Indianapolis Union Station in around 7h 50m.

Airlines
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