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How to get fromDes Plaines to Missouriby plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or subway

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There are 9 ways to get from Des Plaines to Missouri by plane, train (Amtrak), bus (Flixbus, Greyhound), car, train, or subway

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Lambert–St. Louis International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 12m
    $323–703

  2. Fly Chicago O'Hare International Airport to Springfield-Branson National Airport

    cheapest
    1. Fly from Chicago O'Hare International Airport (ORD) to Springfield-Branson National Airport (SGF)plane plane ORD - SGF
    3h 10m
    $61–300

  3. Train

    1. Take the train from Chicago Union Station to Napervilletrain train Bnsf
    2. Take the train from Naperville Amtrak Station to Kansas Citytrain train Southwest Chief
    10h 10m
    $229–361

  4. Bus

    1. Take the bus from O'Hare Multi-Modal Facility to Illinois Terminalbus bus
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Kansas City Bus Stationbus bus
    13h
    $119–175

  5. Drive  509.3 mi

    1. Drive from Des Plaines to Kansas Citycar car 509.3 mi
    8h 39m
    $87–126

  6. Fly Chicago O'Hare International Airport to Columbia Regional Airport

    1. Fly from Chicago O'Hare International Airport (ORD) to Columbia Regional Airport (COU)plane plane ORD - COU
    2h 58m
    $90–335

  7. Fly Chicago O'Hare International Airport to Kansas City

    1. Fly from Chicago O'Hare International Airport (ORD) to Kansas City (MCI)plane plane ORD - MCI
    4h 30m
    $70–440

  8. Train, subway to Chicago Midway International Airport, fly to Lambert–St. Louis International Airport

    1. Take the train from Des Plaines to Chicago OTCtrain train
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 30m
    $94–613

  9. Train, subway to Chicago Midway International Airport, fly to Kansas City

    1. Take the train from Des Plaines to Chicago OTCtrain train
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Kansas City (MCI)plane plane MDW - MCI
    5h 47m
    $116–760

Des Plaines to Missouri by train, foot, and tram

Calendar7Weekly Services
Duration10h 10mAverage Duration
Ticket$229Cheapest Price
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Comparing Your Travel Options

Map of how to get from Des Plaines to Missouri.ExpandLaunch map view
  • Distance: 275.1 mi
  • Duration: 3h 12m

What companies run services between Des Plaines, IL, USA and Missouri, USA?

American Airlines, GoJet Airlines, and United Airlines fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a train from Des Plaines to Metro Center via Chicago OTC, Chicago Union Station, Naperville Amtrak Station, Kansas City, and Union Station in around 10h 10m.

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