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How to get fromDes Plaines to Sioux Fallsby plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

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There are 6 ways to get from Des Plaines to Sioux Falls by plane, train, bus, bus (Flixbus, Greyhound), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Sioux Falls (FSD)plane plane ORD - FSD
    4h 17m
    $57–332

  2. Train, bus via Albert Lea

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    2. Take the bus from St. Paul to Albert Leabus bus
    3. Take the bus from Albert Lea to Sioux Fallsbus bus
    16h 33m
    $225–415

  3. Bus via Madison

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus
    2. Take the bus from Madison to Minneapolisbus bus
    3. Take the bus from Minneapolis to Sioux Fallsbus bus
    18h 18m
    $135–241

  4. Drive 524.5 mi

    1. Drive from Des Plaines to Sioux Fallscar car 524.5 mi
    9h 57m
    $96–139

  5. Train, bus

    1. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from Minneapolis-St. Paul to Sioux Fallsbus bus Jefferson Lines 925
    19h 46m
    $216–393

  6. Bus

    1. Take the bus from Chicago to Minneapolis Bus Stationbus bus Greyhound US0150S
    2. Take the bus from Minneapolis to Sioux Fallsbus bus Jefferson 701 / ...
    20h 30m
    $144–255

Chicago O'Hare International Airport (ORD) to Sioux Falls (FSD) flights

Calendar69Weekly Planes
Duration2h 30mAverage Duration
Ticket$58Cheapest Price
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Questions & Answers

Map of how to get from Des Plaines to Sioux Falls.ExpandLaunch map view
  • Distance: 469.6 mi
  • Duration: 4h 17m

What companies run services between Des Plaines, IL, USA and Sioux Falls, SD, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Sioux Falls (FSD) every 3 hours. Alternatively, you can take a bus from Multi-Modal/Rental Car Facility to The Bus Stop via Madison, Minneapolis, Sioux Falls, and Maple/Career NE corner in around 18h 18m.

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