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How to get fromDes Plaines to Southern Illinois University Edwardsvilleby plane, taxi, train (Amtrak), bus (Flixbus), car, train, subway, or bus

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There are 6 ways to get from Des Plaines to Southern Illinois University Edwardsville by plane, taxi, train (Amtrak), bus (Flixbus), car, train, subway, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago O'Hare International Airport, taxi

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    2. Take the taxi from St-Louis-Airport-STL to Southern Illinois University Edwardsvilletaxi taxi
    3h
    $375–780

  2. Drive 280.8 mi

    cheapest
    1. Drive from Des Plaines to Southern Illinois University Edwardsvillecar car 280.8 mi
    4h 48m
    $52–74

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    7h
    $137–258

  4. Bus

    1. Take the bus from O'Hare Multi-Modal Facility to Illinois Terminalbus bus Chicago Area to Champaign SOUTH / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus 2510 / ...
    8h 36m
    $117–165

  5. Train, subway to Chicago Midway International Airport, fly, taxi

    1. Take the train from Des Plaines to Chicago OTCtrain train
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4. Take the taxi from St-Louis-Airport-STL to Southern Illinois University Edwardsvilletaxi taxi
    4h 23m
    $141–590

  6. Bus to General Mitchell International Airport, fly, taxi

    1. Take the bus from Multi-Modal/Rental Car Facility to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    3. Take the taxi from St-Louis-Airport-STL to Southern Illinois University Edwardsvilletaxi taxi
    4h 11m
    $580–968

Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) flights

Calendar109Weekly Planes
Duration1h 28mAverage Duration
Ticket$60Cheapest Price
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Questions & Answers

Map of how to get from Des Plaines to Southern Illinois University Edwardsville.ExpandLaunch map view
  • Distance: 288 mi
  • Duration: 3h

What companies run services between Des Plaines, IL, USA and Southern Illinois University Edwardsville, IL, USA?

Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $85–190 and the journey takes 4h 46m. Alternatively, you can take a bus from O'Hare Multi-Modal Facility to Southern Illinois University Edwardsville via Illinois Terminal, Champaign Intermodal Trans Ctr, and St Louis Bus Station in around 8h 36m.

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