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How to get fromDes Plaines to St. Louisby plane, train (Amtrak), bus (Flixbus), car, train, subway, or bus

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There are 6 ways to get from Des Plaines to St. Louis by plane, train (Amtrak), bus (Flixbus), car, train, subway, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Chicago O'Hare International Airport

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL)plane plane ORD - STL
    3h 7m
    $273–703

  2. Drive 298.2 mi

    cheapest
    1. Drive from Des Plaines to St. Louiscar car 298.2 mi
    5h 1m
    $55–79

  3. Train (Amtrak)

    1. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    6h 29m
    $97–198

  4. Bus

    1. Take the bus from O'Hare Multi-Modal Facility to Illinois Terminalbus bus Chicago Area to Champaign SOUTH / ...
    2. Take the bus from Champaign Intermodal Trans Ctr to St Louis Bus Stationbus bus FlixBus 2510 / ...
    8h 5m
    $74–110

  5. Train, subway to Chicago Midway International Airport, fly

    1. Take the train from Des Plaines to Chicago OTCtrain train
    2. Take the subway from Clark/Lake to Midwaysubway subway
    3. Fly from Chicago Midway International Airport (MDW) to Lambert–St. Louis International Airport (STL)plane plane MDW - STL
    4h 30m
    $89–563

  6. Bus to General Mitchell International Airport, fly

    1. Take the bus from Multi-Modal/Rental Car Facility to Mitchell Airportbus bus
    2. Fly from General Mitchell International Airport (MKE) to Lambert–St. Louis International Airport (STL)plane plane MKE - STL
    4h 18m
    $518–891

Des Plaines to St. Louis by train and bus (Amtrak)

Calendar38Weekly Services
Duration6h 29mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Des Plaines to St. Louis.ExpandLaunch map view
  • Distance: 275.1 mi
  • Duration: 3h 7m

What companies run services between Des Plaines, IL, USA and St. Louis, MO, USA?

American Airlines, GoJet Airlines, and United Airlines fly from Chicago O'Hare International Airport (ORD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, Amtrak operates a train from Chicago Union Station to St. Louis 5 times a day. Tickets cost $90–190 and the journey takes 4h 46m.

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