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How to get fromDestin to Cape Girardeauby plane, bus, taxi, or car

Find Transport to Cape Girardeau

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There are 8 ways to get from Destin to Cape Girardeau by plane, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Lambert–St. Louis International Airport, bus

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL)plane plane VPS - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 13m
    $156–591

  2. Drive  608.2 mi

    cheapest
    1. Drive from Destin to Cape Girardeaucar car 608.2 mi
    11h 54m
    $111–161

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    5. Take the taxi from Carbondale Intermodal Station to Cape Girardeautaxi taxi
    20h 43m
    $346–482

  4. Fly Destin–Fort Walton Beach Airport to Midamerica St. Louis Airport, bus

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Midamerica St. Louis Airport (BLV)plane plane VPS - BLV
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 28m
    $159–500

  5. Taxi to Northwest Florida Beaches International Airport, fly to Lambert–St. Louis International Airport, bus

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Lambert–St. Louis International Airport (STL)plane plane ECP - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    6h 51m
    $265–764

  6. Taxi to Pensacola International Airport, fly to Lambert–St. Louis International Airport, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Lambert–St. Louis International Airport (STL)plane plane PNS - STL
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h
    $231–643

  7. Fly Destin–Fort Walton Beach Airport to Nashville, bus, taxi

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Nashville (BNA)plane plane VPS - BNA
    2. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    3. Take the taxi from Carbondale Intermodal Station to Cape Girardeautaxi taxi
    8h 30m
    $235–622

  8. Taxi, bus via New South Memphis

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Memphis Bus Stationbus bus
    5. Take the bus from Memphis Bus Station to Cape Girardeaubus bus
    23h 26m
    $282–411

Destin–Fort Walton Beach Airport (VPS) to Lambert–St. Louis International Airport (STL) flights

Calendar21Weekly Planes
Duration3h 8mAverage Duration
Ticket$89Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Cape Girardeau.ExpandLaunch map view
  • Distance: 755 mi
  • Duration: 6h 13m

What companies run services between Destin, FL, USA and Cape Girardeau, MO, USA?

There is no direct connection from Destin to Cape Girardeau. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Lambert–St. Louis International Airport (STL), walk to LAMBERT AIRPORT TERMINAL #1 station, take the train to CIVIC CENTER station, walk to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Cape Girardeau. Alternatively, you can take the taxi to Crestview, take the bus to Tallahassee, walk to N Monroe Street and Silver Slipper Lane, take the bus to C.K. Steele Plaza Gate 22, take the bus to Nashville Bus Station, take the bus to Carbondale Intermodal Station, then take the taxi to Cape Girardeau.

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