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How to get fromDestin to Charlestonby plane, taxi, bus, train, or car

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There are 8 ways to get from Destin to Charleston by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Charleston International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS)plane plane VPS - CHS
    5h 44m
    $110–422

  2. Drive 485.8 mi

    cheapest
    1. Drive from Destin to Charlestoncar car 485.8 mi
    9h 50m
    $89–129

  3. Taxi, bus, train via Tallahassee

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    14h 21m
    $273–435

  4. Taxi to Northwest Florida Beaches International Airport, fly to Charleston International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Charleston International Airport (CHS)plane plane ECP - CHS
    6h 1m
    $214–545

  5. Taxi to Pensacola International Airport, fly to Charleston International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Charleston International Airport (CHS)plane plane PNS - CHS
    6h 36m
    $490–1,354

  6. Fly Destin–Fort Walton Beach Airport to Hilton Head Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Hilton Head Airport (HHH)plane plane VPS - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 51m
    $121–417

  7. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Wildwoodbus bus
    3. Take the bus from Wildwood Amtrak Station to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    18h 47m
    $288–439

  8. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    24h 51m
    $255–401

Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS) flights

Calendar56Weekly Planes
Duration4h 33mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Destin to Charleston.ExpandLaunch map view
  • Distance: 446.9 mi
  • Duration: 5h 44m

What companies run services between Destin, FL, USA and Charleston, SC, USA?

Southwest Airlines, American Airlines, and two other airlines fly from Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS) every 4 hours.

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