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How to get fromDestin to Charlestonby plane, taxi, bus, train, or car

Find Transport to Charleston

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There are 7 ways to get from Destin to Charleston by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Charleston International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS)plane plane VPS - CHS
    5h 35m
    $120–502

  2. Drive  485.8 mi

    cheapest
    1. Drive from Destin to Charlestoncar car 485.8 mi
    9h 50m
    $89–129

  3. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    14h 21m
    $326–470

  4. Taxi to Northwest Florida Beaches International Airport, fly to Charleston International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Charleston International Airport (CHS)plane plane ECP - CHS
    6h 16m
    $224–615

  5. Taxi to Pensacola International Airport, fly to Charleston International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Charleston International Airport (CHS)plane plane PNS - CHS
    6h 21m
    $205–594

  6. Fly Destin–Fort Walton Beach Airport to Hilton Head Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Hilton Head Airport (HHH)plane plane VPS - HHH
    2. Drive from Hilton Head Airport (HHH) to Charlestoncar car
    7h 50m
    $121–437

  7. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Charleston Bus Stationbus bus
    24h 49m
    $265–386

Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS) flights

Calendar59Weekly Planes
Duration4h 26mAverage Duration
Ticket$75Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Charleston.ExpandLaunch map view
  • Distance: 446.9 mi
  • Duration: 5h 35m

What companies run services between Destin, FL, USA and Charleston, SC, USA?

Delta, American Airlines, and Southwest Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS) every 4 hours.

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