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How to get fromDestin to Des Moinesby plane, taxi, bus, or car

Find Transport to Des Moines

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There are 7 ways to get from Destin to Des Moines by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    5h 20m
    $210–821

  2. Drive 1,056 mi

    cheapest
    1. Drive from Destin to Des Moinescar car 1,056 mi
    19h 25m
    $193–279

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to St Louis Bus Stationbus bus
    5. Take the bus from St Louis Bus Station to Des Moinesbus bus
    31h 47m
    $321–537

  4. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    6h
    $314–944

  5. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    6h 12m
    $285–873

  6. Taxi, bus via Carbondale

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Carbondale Intermodal Stationbus bus
    5. Take the bus from Carbondale to St. Louisbus bus
    6. Take the bus from St Louis Bus Station to Des Moinesbus bus
    32h 2m
    $320–547

  7. Taxi, bus #2

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    4. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    34h 47m
    $331–552

Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM) flights

Calendar52Weekly Planes
Duration6h 21mAverage Duration
Ticket$153Cheapest Price
See schedules

Questions & Answers

Map of how to get from Destin to Des Moines.ExpandLaunch map view
  • Distance: 881.2 mi
  • Duration: 5h 20m

What companies run services between Destin, FL, USA and Des Moines, IA, USA?

Delta and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM) every 4 hours.

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