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How to get fromDestin to Des Moinesby plane, taxi, bus, train, or car

Find Transport to Des Moines

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There are 7 ways to get from Destin to Des Moines by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM)plane plane VPS - DSM
    3h 5m
    $141–503

  2. Taxi, bus via Nashville

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Bloomingtonbus bus
    5. Take the bus from Bloomington, IN to Indianapolis Union Stationbus bus
    6. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    34h 12m
    $360–562

  3. Taxi, bus, train

    1. Take the taxi from Destin to Downtown Transfer Stationtaxi taxi
    2. Take the taxi from Blue Angel Pkwy & Gulf Beach Hwy to Mobiletaxi taxi
    3. Take the bus from Mobile to Pascagoulabus bus
    4. Take the train from Pascagoula, MS to New Orleans, LA - Union Passenger Terminaltrain train
    5. Take the train from New Orleans Union Passenger Terminal to Champaign-Urbanatrain train
    6. Take the bus from Champaign Intermodal Trans Ctr to Des Moinesbus bus
    34h 49m
    $823–1,220

  4. Drive  1,056 mi

    1. Drive from Destin to Des Moinescar car 1,056 mi
    19h 25m
    $193–279

  5. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Des Moines (DSM)plane plane ECP - DSM
    5h 58m
    $255–646

  6. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Des Moines (DSM)plane plane PNS - DSM
    5h 59m
    $236–625

  7. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    4. Take the bus from Montgomery Intermodal Center to Indianapolis Union Stationbus bus
    5. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    34h 32m
    $361–527

Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM) flights

Calendar34Weekly Planes
Duration4h 44mAverage Duration
Ticket$83Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Des Moines.ExpandLaunch map view
  • Distance: 881.2 mi
  • Duration: 3h 5m

What companies run services between Destin, FL, USA and Des Moines, IA, USA?

Allegiant Air, Delta, and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Des Moines (DSM) 5 times a day.

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