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How to get fromDestin to Florida Keysby plane, taxi, bus, train, car, or shuttle

Find Transport to Florida Keys

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There are 9 ways to get from Destin to Florida Keys by plane, taxi, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Key West International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW)plane plane VPS - EYW
    7h 1m
    $175–454

  2. Drive  730 mi

    cheapest
    1. Drive from Destin to Florida Keyscar car 730 mi
    14h 25m
    $134–193

  3. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Plant Citybus bus
    3. Take the train from Lakeland to Miami Amtrak Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    20h 10m
    $397–548

  4. Taxi to Pensacola International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Key West International Airport (EYW)plane plane PNS - EYW
    7h 42m
    $260–556

  5. Taxi to Northwest Florida Beaches International Airport, fly to Key West International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Key West International Airport (EYW)plane plane ECP - EYW
    8h 27m
    $289–617

  6. Fly Destin–Fort Walton Beach Airport to Miami International Airport, shuttle

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 42m
    $250–574

  7. Taxi to Pensacola International Airport, fly to Miami International Airport, shuttle

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 32m
    $335–666

  8. Taxi to Pensacola International Airport, fly to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane PNS - FLL
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 3m
    $440–646

  9. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Miamibus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    21h 43m
    $224–295

Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) flights

Calendar28Weekly Planes
Duration4h 29mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Florida Keys.ExpandLaunch map view
  • Distance: 541.7 mi
  • Duration: 7h 1m

What companies run services between Destin, FL, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Key West International Airport (EYW) 4 times a day.

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