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How to get fromDestin to Fort Myersby plane, taxi, bus, or car

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There are 8 ways to get from Destin to Fort Myers by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Ft. Myers

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Ft. Myers (RSW)plane plane VPS - RSW
    6h 26m
    $131–475

  2. Drive 502.1 mi

    cheapest
    1. Drive from Destin to Fort Myerscar car 502.1 mi
    9h 33m
    $92–133

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Fort Myersbus bus Houston
    11h 8m
    $184–230

  4. Taxi to Northwest Florida Beaches International Airport, fly to Ft. Myers

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Ft. Myers (RSW)plane plane ECP - RSW
    7h 6m
    $235–598

  5. Taxi to Pensacola International Airport, fly to Ft. Myers

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Ft. Myers (RSW)plane plane PNS - RSW
    7h 15m
    $501–957

  6. Fly Destin–Fort Walton Beach Airport to Miami International Airport, bus

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take the bus from Miami Airport Station to Fort Myers Bus Stopbus bus
    6h 34m
    $129–425

  7. Taxi to Pensacola International Airport, fly to Miami International Airport, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take the bus from Miami Airport Station to Fort Myers Bus Stopbus bus
    7h 31m
    $209–497

  8. Taxi to Pensacola International Airport, fly to Tampa, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Tampa (TPA)plane plane PNS - TPA
    3. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus
    7h 14m
    $309–689

Destin–Fort Walton Beach Airport (VPS) to Ft. Myers (RSW) flights

Calendar56Weekly Planes
Duration5h 34mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Destin to Fort Myers.ExpandLaunch map view
  • Distance: 430.3 mi
  • Duration: 6h 26m

What companies run services between Destin, FL, USA and Fort Myers, FL, USA?

Delta, American Airlines, and Southwest Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Ft. Myers (RSW) every 4 hours.

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