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How to get fromDestin to Gatlinburgby plane, taxi, bus, or car

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There are 6 ways to get from Destin to Gatlinburg by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Mcghee Tyson Airport, taxi

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    2. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    2h 55m
    $323–1,010

  2. Drive  497.1 mi

    cheapest
    1. Drive from Destin to Gatlinburgcar car 497.1 mi
    10h 32m
    $91–131

  3. Taxi, bus, drive

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from Asheville, NC to Gatlinburgcar car
    23h 30m
    $262–383

  4. Taxi to Northwest Florida Beaches International Airport, fly to Mcghee Tyson Airport, taxi

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS)plane plane ECP - TYS
    3. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    5h 18m
    $427–1,133

  5. Taxi to Pensacola International Airport, fly to Mcghee Tyson Airport, taxi

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    3. Take the taxi from Mcghee Tyson Airport (TYS) to Gatlinburgtaxi taxi
    5h 24m
    $408–1,062

  6. Fly Destin–Fort Walton Beach Airport to Asheville Regional Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Asheville Regional Airport (AVL)plane plane VPS - AVL
    2. Drive from Asheville-Airport-AVL to Gatlinburgcar car
    5h 46m
    $113–413

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar36Weekly Planes
Duration2h 11mAverage Duration
Ticket$118Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Gatlinburg.ExpandLaunch map view
  • Distance: 450.6 mi
  • Duration: 2h 55m

What companies run services between Destin, FL, USA and Gatlinburg, TN, USA?

There is no direct connection from Destin to Gatlinburg. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Mcghee Tyson Airport (TYS), then take the taxi to Gatlinburg. Alternatively, you can take the taxi to Crestview, take the bus to Tallahassee, walk to N Monroe Street and Silver Slipper Lane, take the bus to C.K. Steele Plaza Gate 22, take the bus to Atlanta Bus Station, take the bus to Winston Salem(Trans Center), take the bus to Asheville, NC, then drive to Gatlinburg.

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