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How to get fromDestin to Great Smoky Mountainsby plane, car, taxi, or bus

Find Transport to Great Smoky Mountains

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There are 6 ways to get from Destin to Great Smoky Mountains by plane, car, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    3h 39m
    $148–666

  2. Drive 487.7 mi

    cheapest
    1. Drive from Destin to Great Smoky Mountainscar car 487.7 mi
    10h 20m
    $89–129

  3. Taxi, bus, drive

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from Asheville, NC to Great Smoky Mountainscar car
    23h 36m
    $256–417

  4. Fly Destin–Fort Walton Beach Airport to Asheville Regional Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Asheville Regional Airport (AVL)plane plane VPS - AVL
    2. Drive from Asheville-Airport-AVL to Great Smoky Mountainscar car
    5h 56m
    $112–402

  5. Taxi to Northwest Florida Beaches International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS)plane plane ECP - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    5h 59m
    $252–789

  6. Taxi to Pensacola International Airport, fly to Mcghee Tyson Airport, drive

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    3. Drive from Mcghee Tyson Airport (TYS) to Great Smoky Mountainscar car
    6h 19m
    $223–668

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar21Weekly Planes
Duration3hAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Destin to Great Smoky Mountains.ExpandLaunch map view
  • Distance: 470.6 mi
  • Duration: 3h 39m

What companies run services between Destin, FL, USA and Great Smoky Mountains, TN, USA?

There is no direct connection from Destin to Great Smoky Mountains. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Mcghee Tyson Airport (TYS), then drive to Great Smoky Mountains. Alternatively, you can take the taxi to Crestview, take the bus to Tallahassee, walk to N Monroe Street and Silver Slipper Lane, take the bus to C.K. Steele Plaza Gate 22, take the bus to Atlanta Bus Station, take the bus to Winston Salem(Trans Center), take the bus to Asheville, NC, then drive to Great Smoky Mountains.

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