Rome2Rio

How to get fromDestin to Greenevilleby plane, car, taxi, bus, or train

Find Transport to Greeneville

See all options

There are 8 ways to get from Destin to Greeneville by plane, car, taxi, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Mcghee Tyson Airport, drive

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Greenevillecar car
    3h 18m
    $153–672

  2. Drive 539.8 mi

    cheapest
    1. Drive from Destin to Greenevillecar car 539.8 mi
    11h 17m
    $99–143

  3. Taxi, bus, drive

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Winston Salem(Trans Center)bus bus
    5. Take the bus from Winston Salem(Trans Center) to Asheville, NCbus bus
    6. Drive from Asheville, NC to Greenevillecar car
    22h 58m
    $258–412

  4. Taxi, bus, train, drive

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Plant Citybus bus
    3. Take the train from Lakeland Amtrak Station to Carytrain train
    4. Take the train from Cary to Greensborotrain train
    5. Take the bus from Greensboro Bus Stop to Asheville, NCbus bus
    6. Drive from Asheville, NC to Greenevillecar car
    32h 2m
    $513–860

  5. Fly Destin–Fort Walton Beach Airport to Tri-Cities Regional Tn/Va Airport, taxi

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane VPS - TRI
    2. Take the taxi from Tri-Cities-Regional-Airport-TRI to Greenevilletaxi taxi
    5h 18m
    $213–600

  6. Taxi to Northwest Florida Beaches International Airport, fly to Tri-Cities Regional Tn/Va Airport, taxi

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane ECP - TRI
    3. Take the taxi from Tri-Cities-Regional-Airport-TRI to Greenevilletaxi taxi
    5h 32m
    $317–723

  7. Taxi to Pensacola International Airport, fly to Tri-Cities Regional Tn/Va Airport, taxi

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Tri-Cities Regional Tn/Va Airport (TRI)plane plane PNS - TRI
    3. Take the taxi from Tri-Cities-Regional-Airport-TRI to Greenevilletaxi taxi
    6h 9m
    $293–672

  8. Fly Destin–Fort Walton Beach Airport to Asheville Regional Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Asheville Regional Airport (AVL)plane plane VPS - AVL
    2. Drive from ART Station to Greenevillecar car
    6h 44m
    $109–386

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar26Weekly Planes
Duration2h 39mAverage Duration
Ticket$97Cheapest Price
See schedules

Questions & Answers

Map of how to get from Destin to Greeneville.ExpandLaunch map view
  • Distance: 494.1 mi
  • Duration: 3h 18m

What companies run services between Destin, FL, USA and Greeneville, TN, USA?

There is no direct connection from Destin to Greeneville. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Mcghee Tyson Airport (TYS), then drive to Greeneville. Alternatively, you can take the taxi to Crestview, take the bus to Tallahassee, walk to N Monroe Street and Silver Slipper Lane, take the bus to C.K. Steele Plaza Gate 22, take the bus to Atlanta Bus Station, take the bus to Winston Salem(Trans Center), take the bus to Asheville, NC, then drive to Greeneville.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound