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How to get fromDestin to Greenvilleby plane, taxi, bus, or car

Find Transport to Greenville

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There are 4 ways to get from Destin to Greenville by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP)plane plane VPS - GSP
    3h 59m
    $158–575

  2. Drive 447.8 mi

    cheapest
    1. Drive from Destin to Greenvillecar car 447.8 mi
    8h 53m
    $82–118

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    15h 57m
    $239–429

  4. Fly to Asheville Regional Airport, taxi

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Asheville Regional Airport (AVL)plane plane VPS - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 52m
    $238–550

Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) flights

Calendar69Weekly Planes
Duration4h 17mAverage Duration
Ticket$81Cheapest Price
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Questions & Answers

Map of how to get from Destin to Greenville.ExpandLaunch map view
  • Distance: 422.5 mi
  • Duration: 3h 59m

What companies run services between Destin, FL, USA and Greenville, SC, USA?

Delta, Southwest Airlines, and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) every 3 hours.

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