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How to get fromDestin to Knoxvilleby plane, taxi, bus, car, or train

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There are 7 ways to get from Destin to Knoxville by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    2h 3m
    $198–820

  2. Drive 510.9 mi

    cheapest
    1. Drive from Destin to Knoxvillecar car 510.9 mi
    8h 50m
    $94–135

  3. Taxi, bus via Jacksonville

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the bus from Jacksonville to New York City Chinatownbus bus
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 48m
    $434–607

  4. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS)plane plane ECP - TYS
    4h 35m
    $302–943

  5. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    4h 44m
    $283–872

  6. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to New York Midtownbus bus
    5. Take the bus from New York to Knoxvillebus bus Nyc
    42h 43m
    $479–710

  7. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Wildwoodbus bus
    3. Take the bus from Wildwood Amtrak Station to Jacksonvillebus bus
    4. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York to Knoxvillebus bus Nyc
    44h 56m
    $642–1,108

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar10Weekly Planes
Duration2h 50mAverage Duration
Ticket$108Cheapest Price
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Questions & Answers

Map of how to get from Destin to Knoxville.ExpandLaunch map view
  • Distance: 424.2 mi
  • Duration: 2h 3m

What companies run services between Destin, FL, USA and Knoxville, TN, USA?

Allegiant Air, Southwest Airlines, and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) once daily.

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