Rome2Rio

How to get fromDestin to Knoxvilleby plane, taxi, bus, car, or train

Find Transport to Knoxville

See all options

There are 8 ways to get from Destin to Knoxville by plane, taxi, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    2h 4m
    $198–720

  2. Drive 510.9 mi

    cheapest
    1. Drive from Destin to Knoxvillecar car 510.9 mi
    8h 50m
    $94–135

  3. Taxi, bus via Jacksonville

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the bus from Jacksonville to New York City Chinatownbus bus
    5. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    40h 48m
    $457–642

  4. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Mcghee Tyson Airport (TYS)plane plane ECP - TYS
    4h 24m
    $297–843

  5. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Mcghee Tyson Airport (TYS)plane plane PNS - TYS
    4h 44m
    $273–772

  6. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to New York Midtownbus bus
    5. Take the bus from New York to Knoxvillebus bus Nyc
    42h 43m
    $504–755

  7. Taxi, bus #2

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Port Authority Bus Terminalbus bus
    5. Take the bus from New York to Knoxvillebus bus Nyc
    44h 34m
    $514–805

  8. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Wildwoodbus bus
    3. Take the bus from Wildwood Amtrak Station to Jacksonvillebus bus
    4. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train
    5. Take the bus from New York to Knoxvillebus bus Nyc
    44h 56m
    $707–1,168

Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) flights

Calendar22Weekly Planes
Duration2h 35mAverage Duration
Ticket$99Cheapest Price
See schedules

Questions & Answers

Map of how to get from Destin to Knoxville.ExpandLaunch map view
  • Distance: 424.2 mi
  • Duration: 2h 4m

What companies run services between Destin, FL, USA and Knoxville, TN, USA?

Allegiant Air, Delta, and Southwest Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS) 3 times a day.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound