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How to get fromDestin to Lexingtonby plane, car, taxi, or bus

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There are 8 ways to get from Destin to Lexington by plane, car, taxi, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Louisville International Airport, drive

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    3h 39m
    $142–551

  2. Drive 664.4 mi

    cheapest
    1. Drive from Destin to Lexingtoncar car 664.4 mi
    11h 20m
    $122–176

  3. Taxi, bus, drive

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    23h 51m
    $255–396

  4. Fly to Covington, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Covington (CVG)plane plane VPS - CVG
    2. Drive from Covington (CVG) to Lexingtoncar car
    3h 49m
    $158–622

  5. Fly to Blue Grass Airport

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX)plane plane VPS - LEX
    6h 14m
    $175–802

  6. Fly to Mcghee Tyson Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Mcghee Tyson Airport (TYS)plane plane VPS - TYS
    2. Drive from Mcghee Tyson Airport (TYS) to Lexingtoncar car
    4h 58m
    $168–700

  7. Fly to Tri-State Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Tri-State Airport (HTS)plane plane VPS - HTS
    2. Drive from Tri-State Airport (HTS) to Lexingtoncar car
    7h 47m
    $134–465

  8. Taxi, bus, drive via Evansville

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Evansville Bus Stationbus bus
    5. Take the bus from Evansville, IN to Corydon, INbus bus
    6. Drive from Middletown Station @ Target to Lexingtoncar car
    25h 2m
    $337–513

Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF) flights

Calendar55Weekly Planes
Duration3h 31mAverage Duration
Ticket$85Cheapest Price
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Questions & Answers

Map of how to get from Destin to Lexington.ExpandLaunch map view
  • Distance: 628.6 mi
  • Duration: 3h 39m

What companies run services between Destin, FL, USA and Lexington, KY, USA?

Delta and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX) every 4 hours.

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