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How to get fromDestin to Louisvilleby plane, taxi, bus, or car

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There are 7 ways to get from Destin to Louisville by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Louisville International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF)plane plane VPS - SDF
    3h 22m
    $144–653

  2. Drive  622.8 mi

    cheapest
    1. Drive from Destin to Louisvillecar car 622.8 mi
    10h 38m
    $114–165

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus
    18h 57m
    $230–362

  4. Fly Destin–Fort Walton Beach Airport to Blue Grass Airport, drive

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Blue Grass Airport (LEX)plane plane VPS - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 26m
    $121–439

  5. Taxi to Northwest Florida Beaches International Airport, fly to Louisville International Airport

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Louisville International Airport (SDF)plane plane ECP - SDF
    5h 35m
    $248–776

  6. Taxi to Pensacola International Airport, fly to Louisville International Airport

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Louisville International Airport (SDF)plane plane PNS - SDF
    5h 44m
    $224–705

  7. Taxi, bus via Preston @ Vim

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Nashville Bus Stationbus bus
    4. Take the bus from Tornado Bus Co - Nashville to La Tropicana - Louisville, KYbus bus
    20h 19m
    $244–377

Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF) flights

Calendar48Weekly Planes
Duration3h 13mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Destin to Louisville.ExpandLaunch map view
  • Distance: 555.2 mi
  • Duration: 3h 22m

What companies run services between Destin, FL, USA and Louisville, KY, USA?

Allegiant Air, Southwest Airlines, and Delta fly from Destin–Fort Walton Beach Airport (VPS) to Louisville International Airport (SDF) every 4 hours.

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