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How to get fromDestin to Panama Cityby plane, car, or taxi

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There are 5 ways to get from Destin to Panama City by plane, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Tocumen International Airport (PTY)plane plane VPS - PTY
    8h 13m
    $201–638

  2. Drive 5,229.5 km

    1. Drive from Destin to Panama Citycar car 5,229.5 km
    2d 22h
    $716–1,034

  3. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Tocumen International Airport (PTY)plane plane PNS - PTY
    8h 6m
    $276–660

  4. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Tocumen International Airport (PTY)plane plane ECP - PTY
    8h 38m
    $325–811

  5. Drive to Mobile Regional Airport, fly

    1. Drive from Destin to Mobile-Airport-MOBcar car
    2. Fly from Mobile Regional Airport (MOB) to Tocumen International Airport (PTY)plane plane MOB - PTY
    10h 17m
    $209–669

Destin–Fort Walton Beach Airport (VPS) to Tocumen International Airport (PTY) flights

Calendar28Weekly Planes
Duration8h 3mAverage Duration
Ticket$127Cheapest Price
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Questions & Answers

Map of how to get from Destin to Panama City.ExpandLaunch map view
  • Distance: 2,545.7 km
  • Duration: 8h 13m

What companies run services between Destin, FL, USA and Panama City, Panama?

Delta, American Airlines, and two other airlines fly from Destin–Fort Walton Beach Airport (VPS) to Tocumen International Airport (PTY) 4 times a day.

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