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How to get fromDestin to Port Saint Lucieby plane, bus, taxi, or car

Find Transport to Port Saint Lucie

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There are 8 ways to get from Destin to Port Saint Lucie by plane, bus, taxi, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Miami International Airport, bus

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    6h 10m
    $131–416

  2. Drive  498.5 mi

    cheapest
    1. Drive from Destin to Port Saint Luciecar car 498.5 mi
    9h 10m
    $89–128

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Ocalabus bus
    3. Take the bus from Ocala, FL to Kissimmee -1471 East Osceola Parkwaybus bus
    4. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    11h 56m
    $243–317

  4. Fly Destin–Fort Walton Beach Airport to Melbourne International Airport, taxi, bus

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Melbourne International Airport (MLB)plane plane VPS - MLB
    2. Take the taxi from Melbourne International Airport (MLB) to Sebastiantaxi taxi
    3. Take the bus from Sebastian to Port St Luciebus bus
    9h 30m
    $206–562

  5. Taxi to Pensacola International Airport, fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane PNS - FLL
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    6h 45m
    $298–487

  6. Taxi to Pensacola International Airport, fly to Miami International Airport, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take the bus from Sheridan Tri-Rail Station to Fort Piercebus bus
    7h 3m
    $216–528

  7. Taxi to Pensacola International Airport, fly to Orlando, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Orlando (MCO)plane plane PNS - MCO
    3. Take the bus from Kissimmee -1471 East Osceola Parkway to Fort Piercebus bus
    7h 19m
    $237–376

  8. Taxi, bus via Tallahassee

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Orlando Bus Stationbus bus
    4. Take the bus from Orlando Bus Station to Port St Luciebus bus
    14h 6m
    $202–277

Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA) flights

Calendar14Weekly Planes
Duration3h 27mAverage Duration
Ticket$54Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to Port Saint Lucie.ExpandLaunch map view
  • Distance: 634.3 mi
  • Duration: 6h 10m

What companies run services between Destin, FL, USA and Port Saint Lucie, FL, USA?

There is no direct connection from Destin to Port Saint Lucie. However, you can take the taxi to Destin–Fort Walton Beach Airport (VPS) airport, fly to Miami International Airport (MIA), walk to Miami International Airport, take the vehicle to Miami Airport Station, walk to Miami, Airport Intermodal Station, take the train to Sheridan Street Station, walk to Sheridan Tri-Rail Station, then take the bus to Fort Pierce. Alternatively, you can take the taxi to Crestview, take the bus to Ocala, take the taxi to Ocala, FL, take the bus to Kissimmee -1471 East Osceola Parkway, then take the bus to Fort Pierce.

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