Rome2Rio

How to get fromDestin to Port Saint Lucieby taxi, plane, bus, car, or train

Find Transport to Port Saint Lucie

See all options

There are 9 ways to get from Destin to Port Saint Lucie by taxi, plane, bus, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Pensacola International Airport, fly to Orlando, bus

    best
    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Orlando (MCO)plane plane PNS - MCO
    3. Take the bus from Orlando RedCoach Station to Fort Piercebus bus
    6h 6m
    $243–1,109

  2. Drive 498.5 mi

    cheapest
    1. Drive from Destin to Port Saint Luciecar car 498.5 mi
    9h 10m
    $91–132

  3. Taxi, bus via Marion Oaks

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Ocalabus bus
    3. Take the bus from Ocala to Fort Piercebus bus
    11h 6m
    $239–335

  4. Fly Destin–Fort Walton Beach Airport to Miami International Airport, train, bus

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Miami International Airport (MIA)plane plane VPS - MIA
    2. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    3. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    6h 14m
    $136–426

  5. Fly Destin–Fort Walton Beach Airport to Melbourne International Airport, taxi, bus

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Melbourne International Airport (MLB)plane plane VPS - MLB
    2. Take the taxi from Melbourne International Airport (MLB) to Sebastiantaxi taxi
    3. Take the bus from Sebastian to Port St Luciebus bus
    8h 24m
    $209–553

  6. Taxi to Pensacola International Airport, fly to Miami International Airport, train, bus

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Miami International Airport (MIA)plane plane PNS - MIA
    3. Take the train from Miami Airport Station to Fort Lauderdale Stationtrain train
    4. Take the bus from Fort Lauderdale - Broward Blvd Park and Ride to Fort Piercebus bus
    7h 11m
    $216–498

  7. Fly Destin–Fort Walton Beach Airport to President Donald J. Trump International Airport, bus

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to President Donald J. Trump International Airport (PBI)plane plane VPS - PBI
    2. Take the bus from WPB ITC at BAY D to GATLIN BLVD at I-95 P/R LOTbus bus
    9h 7m
    $147–527

  8. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee FSU to Fort Piercebus bus
    12h 40m
    $233–364

  9. Taxi, bus via Tallahassee

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Orlandobus bus
    4. Take the bus from Orlando to Port St Luciebus bus
    14h 26m
    $195–282

Pensacola International Airport (PNS) to Orlando (MCO) flights

Calendar44Weekly Planes
Duration2h 46mAverage Duration
Ticket$64Cheapest Price
See schedules

Questions & Answers

Map of how to get from Destin to Port Saint Lucie.ExpandLaunch map view
  • Distance: 550.9 mi
  • Duration: 6h 6m

What companies run services between Destin, FL, USA and Port Saint Lucie, FL, USA?

There is no direct connection from Destin to Port Saint Lucie. However, you can take the taxi to Pensacola-Airport-PNS airport, fly to Orlando (MCO), walk to Orlando International Airport, take the line 42 bus to Mccoy Rd & Gondola Dr, walk to Orlando RedCoach Station, then take the bus to Fort Pierce. Alternatively, you can take the taxi to Crestview, take the bus to Ocala, take the taxi to Ocala, then take the bus to Fort Pierce.

Airlines
Train operators
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound