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How to get fromDestin to South Carolinaby plane, taxi, bus, train, or car

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There are 10 ways to get from Destin to South Carolina by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP)plane plane VPS - GSP
    3h 59m
    $158–575

  2. Drive 485.8 mi

    cheapest
    1. Drive from Destin to Charlestoncar car 485.8 mi
    9h 50m
    $89–129

  3. Taxi, bus, train via Tallahassee

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    14h 21m
    $273–435

  4. Fly Destin–Fort Walton Beach Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Charlotte Douglas International Airport (CLT)plane plane VPS - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    2h 47m
    $208–650

  5. Taxi to Northwest Florida Beaches International Airport, fly to Charlotte Douglas International Airport, taxi

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Charlotte Douglas International Airport (CLT)plane plane ECP - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 28m
    $312–763

  6. Fly Destin–Fort Walton Beach Airport to Asheville Regional Airport, taxi

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Asheville Regional Airport (AVL)plane plane VPS - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    4h 52m
    $238–540

  7. Taxi to Pensacola International Airport, fly to Charlotte Douglas International Airport, taxi

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Charlotte Douglas International Airport (CLT)plane plane PNS - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 38m
    $288–702

  8. Fly Destin–Fort Walton Beach Airport to Columbia

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Columbia (CAE)plane plane VPS - CAE
    5h 10m
    $185–852

  9. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the bus from Jacksonville to Savannah Bus Stationbus bus
    5. Take the bus from Bluffton Transfer Center to Walmartbus bus 320
    6. Take the taxi from Walmart to Dorchester Village Shopping Center Park & Ridetaxi taxi
    17h 33m

  10. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Wildwoodbus bus
    3. Take the bus from Wildwood Amtrak Station to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    18h 47m
    $288–439

Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) flights

Calendar69Weekly Planes
Duration4h 17mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Destin to South Carolina.ExpandLaunch map view
  • Distance: 422.5 mi
  • Duration: 3h 59m

What companies run services between Destin, FL, USA and South Carolina, USA?

Delta, Southwest Airlines, and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) every 3 hours.

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