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How to get fromDestin to South Carolinaby plane, taxi, bus, train, or car

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There are 8 ways to get from Destin to South Carolina by plane, taxi, bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Destin–Fort Walton Beach Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP)plane plane VPS - GSP
    3h 57m
    $148–545

  2. Drive  485.8 mi

    cheapest
    1. Drive from Destin to Charlestoncar car 485.8 mi
    9h 50m
    $83–120

  3. Taxi, bus, train

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Jacksonvillebus bus
    4. Take the train from Jacksonville to Charleston Amtrak Stationtrain train
    13h 39m
    $337–483

  4. Fly Destin–Fort Walton Beach Airport to Charlotte Douglas International Airport, taxi

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Charlotte Douglas International Airport (CLT)plane plane VPS - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    2h 48m
    $213–700

  5. Taxi to Northwest Florida Beaches International Airport, fly to Charlotte Douglas International Airport, taxi

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Charlotte Douglas International Airport (CLT)plane plane ECP - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 27m
    $312–823

  6. Fly Destin–Fort Walton Beach Airport to Charleston International Airport

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Charleston International Airport (CHS)plane plane VPS - CHS
    4h 51m
    $120–502

  7. Taxi to Pensacola International Airport, fly to Charlotte Douglas International Airport, taxi

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Charlotte Douglas International Airport (CLT)plane plane PNS - CLT
    3. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    3h 34m
    $293–802

  8. Fly Destin–Fort Walton Beach Airport to Columbia

    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Columbia (CAE)plane plane VPS - CAE
    5h 9m
    $100–402

Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) flights

Calendar78Weekly Planes
Duration4h 35mAverage Duration
Ticket$74Cheapest Price
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Comparing Your Travel Options

Map of how to get from Destin to South Carolina.ExpandLaunch map view
  • Distance: 422.5 mi
  • Duration: 3h 57m

What companies run services between Destin, FL, USA and South Carolina, USA?

Delta, Southwest Airlines, and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) every 2 hours.

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