Rome2Rio

How to get fromDestin to Spartanburgby plane, taxi, bus, or car

Find Transport to Spartanburg

See all options

There are 6 ways to get from Destin to Spartanburg by plane, taxi, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Destin–Fort Walton Beach Airport

    best
    1. Fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP)plane plane VPS - GSP
    3h 54m
    $183–670

  2. Drive  474.9 mi

    cheapest
    1. Drive from Destin to Spartanburgcar car 474.9 mi
    9h 25m
    $87–126

  3. Taxi, bus

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Spartanburgbus bus
    14h 48m
    $219–313

  4. Taxi to Northwest Florida Beaches International Airport, fly

    1. Take the taxi from Destin to Northwest Florida Beaches International Airport (ECP)taxi taxi
    2. Fly from Northwest Florida Beaches International Airport (ECP) to Greenville–Spartanburg International Airport (GSP)plane plane ECP - GSP
    4h 38m
    $287–793

  5. Taxi to Pensacola International Airport, fly

    1. Take the taxi from Destin to Pensacola-Airport-PNStaxi taxi
    2. Fly from Pensacola International Airport (PNS) to Greenville–Spartanburg International Airport (GSP)plane plane PNS - GSP
    4h 46m
    $263–722

  6. Taxi, bus via Sandy Springs

    1. Take the taxi from Destin to Crestviewtaxi taxi
    2. Take the bus from Crestview to Tallahasseebus bus
    3. Take the bus from Tallahassee to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Servicios Zapata - Spartanburgbus bus
    16h 41m
    $225–324

Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) flights

Calendar68Weekly Planes
Duration4h 20mAverage Duration
Ticket$87Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Destin to Spartanburg.ExpandLaunch map view
  • Distance: 429.4 mi
  • Duration: 3h 54m

What companies run services between Destin, FL, USA and Spartanburg, SC, USA?

Delta, Southwest Airlines, and American Airlines fly from Destin–Fort Walton Beach Airport (VPS) to Greenville–Spartanburg International Airport (GSP) every 3 hours.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound