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How to get fromDetroit Airport (DTW) to Mayo Clinicby plane, train, bus, car, bus (Amtrak), or bus (Flixbus)

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There are 7 ways to get from Detroit Airport (DTW) to Mayo Clinic by plane, train, bus, car, bus (Amtrak), or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Detroit (DTW) to Rochester (RST)plane plane DTW - RST
    4h 52m
    $77–475

  2. Train, bus via Madison

    1. Take the train from Dearborn to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 25m
    $157–312

  3. Train, bus

    1. Take the train from Dearborn to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    17h 23m
    $230–492

  4. Drive 611.2 mi

    1. Drive from Detroit Airport (DTW) to Mayo Cliniccar car 611.2 mi
    10h 7m
    $112–162

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Detroit (DTW) to Minneapolis–Saint Paul International Airport (MSP)plane plane DTW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 41m
    $528–1,254

  6. Bus via Chicago

    1. Take the bus from Dearborn to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 46m
    $167–262

  7. Bus

    1. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus FlixBus 2550
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    16h 50m
    $127–197

Detroit Airport (DTW) to Mayo Clinic by bus, train, and foot

Calendar7Weekly Services
Duration16h 25mAverage Duration
Ticket$157Cheapest Price
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Questions & Answers

Map of how to get from Detroit Airport (DTW) to Mayo Clinic.ExpandLaunch map view
  • Distance: 485 mi
  • Duration: 4h 52m

What companies run services between Detroit Airport (DTW), USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Detroit (DTW) to Rochester (RST) every 2 hours. Alternatively, you can take a bus from Metro Airport McNamara Terminal to Mayo Clinic via Dearborn, Chicago Union Station, W Jackson Blvd, after S Clinton St, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 16h 46m.

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