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How to get fromDetroit, MI to St. Louisby plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 7 ways to get from Detroit, MI to St. Louis by plane, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Detroit

    best
    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    4h 17m
    $405–955

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus Greyhound US0112
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    10h 30m
    $78–150

  3. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 12m
    $182–382

  4. Drive 517.1 mi

    1. Drive from Detroit, MI to St. Louiscar car 517.1 mi
    8h 50m
    $95–137

  5. Drive to Capital Region International Airport, fly

    1. Drive from Detroit, MI to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    5h 46m
    $120–677

  6. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    6h 47m
    $521–952

  7. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    14h
    $97–165

Detroit, MI to St. Louis by bus (Greyhound)

Calendar7Weekly Buses
Duration10h 30mAverage Duration
Ticket$78Cheapest Price
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Questions & Answers

Map of how to get from Detroit, MI to St. Louis.ExpandLaunch map view
  • Distance: 475.2 mi
  • Duration: 4h 17m

What companies run services between Detroit, MI, USA and St. Louis, MO, USA?

Delta and Southwest Airlines fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Detroit Bus Station to St Louis Bus Station via Indianapolis Union Station in around 10h 30m.

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