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How to get fromDetroit to Cape Girardeauby plane, taxi, train, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

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There are 9 ways to get from Detroit to Cape Girardeau by plane, taxi, train, bus (Greyhound), car, bus, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport, taxi

    best
    1. Fly from Detroit (DTW) to Williamson County Regional Airport (MWA)plane plane DTW - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi taxi
    7h 28m
    $207–582

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    13h 39m
    $102–194

  3. Train, taxi

    1. Take the train from Detroit to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Carbondaletrain train
    3. Take the taxi from Carbondale to Cape Girardeautaxi taxi
    12h 36m
    $291–525

  4. Drive 580.3 mi

    1. Drive from Detroit to Cape Girardeaucar car 580.3 mi
    10h
    $106–153

  5. Fly to Barkley Regional Airport, taxi

    1. Fly from Detroit (DTW) to Barkley Regional Airport (PAH)plane plane DTW - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi taxi
    7h 20m
    $222–622

  6. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    7h 18m
    $479–999

  7. Fly to Cape Girardeau Municipal Airport

    1. Fly from Detroit (DTW) to Cape Girardeau Municipal Airport (CGI)plane plane DTW - CGI
    6h 48m
    $185–730

  8. Train, bus

    1. Take the train from Detroit to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    14h 1m
    $205–419

  9. Bus via Auburn Gresham

    1. Take the bus from Detroit Bus Station to Chicagobus bus
    2. Take the bus from Chicago to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    17h 4m
    $130–221

Detroit (DTW) to Williamson County Regional Airport (MWA) flights

Calendar26Weekly Planes
Duration4h 48mAverage Duration
Ticket$76Cheapest Price
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Questions & Answers

Map of how to get from Detroit to Cape Girardeau.ExpandLaunch map view
  • Distance: 508.2 mi
  • Duration: 7h 28m

What companies run services between Detroit, MI, USA and Cape Girardeau, MO, USA?

You can take a bus from Detroit Bus Station to Cape Girardeau via Indianapolis Union Station, St Louis Bus Station, and Cape Girardeau in around 13h 39m. Alternatively, United Airlines, Corporate Flight Management Inc, and Delta fly from Detroit (DTW) to Cape Girardeau Municipal Airport (CGI) twice daily.

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