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How to get fromDetroit to East Saint Louisby plane, bus (Greyhound), train (Amtrak), car, or bus (Flixbus)

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There are 6 ways to get from Detroit to East Saint Louis by plane, bus (Greyhound), train (Amtrak), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Detroit

    best
    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    4h 22m
    $455–955

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus Greyhound US0112
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    10h 46m
    $80–152

  3. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    11h 8m
    $183–377

  4. Drive 515.6 mi

    1. Drive from Detroit to East Saint Louiscar car 515.6 mi
    8h 48m
    $95–136

  5. Drive to Capital Region International Airport, fly

    1. Drive from Detroit to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    6h
    $120–677

  6. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    14h 11m
    $102–177

Detroit to East Saint Louis by bus and train (Greyhound)

Calendar14Weekly Services
Duration10h 46mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Detroit to East Saint Louis.ExpandLaunch map view
  • Distance: 479.2 mi
  • Duration: 4h 22m

What companies run services between Detroit, MI, USA and East Saint Louis, IL, USA?

Delta and Southwest Airlines fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Detroit Bus Station to 5TH & MISSOURI station via Indianapolis Union Station, St Louis Bus Station, and CIVIC CENTER station in around 10h 46m.

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Need to know: Greyhound

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