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How to get fromDetroit to Hannibalby train (Amtrak), bus, train, car, plane, shuttle, or bus (Greyhound)

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There are 6 ways to get from Detroit to Hannibal by train (Amtrak), bus, train, car, plane, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train Carl Sandburg / ...
    10h 57m
    $223–440

  2. Drive 551.8 mi

    cheapest
    1. Drive from Detroit to Hannibalcar car 551.8 mi
    9h 12m
    $101–146

  3. Bus, train (Amtrak)

    1. Take the bus from Detroit to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the train from Chicago Union Station to Quincy Amtrak Stationtrain train Carl Sandburg / ...
    12h 34m
    $232–392

  4. Fly from Detroit, shuttle

    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    6h 40m
    $620–975

  5. Bus (Greyhound)

    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Quincy Public Transit Hubbus bus
    14h 35m
    $144–249

  6. Bus to Cleveland-Hopkins International Airport, fly, shuttle

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3. Take a shuttle bus from St. Louis to Hannibalshuttle bus
    9h 19m
    $534–968

Detroit (DTW) to Lambert–St. Louis International Airport (STL) flights

Calendar50Weekly Planes
Duration2h 14mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Detroit to Hannibal.ExpandLaunch map view
  • Distance: 609.4 mi
  • Duration: 10h 57m

What companies run services between Detroit, MI, USA and Hannibal, MO, USA?

You can take a train from Detroit to Hannibal via Chicago Union Station and Quincy Amtrak Station in around 10h 57m. Alternatively, you can take a bus from Detroit Bus Station to Hannibal via Indianapolis Union Station, St Louis Bus Station, and Quincy Public Transit Hub in around 14h 35m.

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