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How to get fromDetroit to Kirksvilleby train (Amtrak), bus, train, car, plane, or shuttle

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There are 10 ways to get from Detroit to Kirksville by train (Amtrak), bus, train, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train (Amtrak)

    best
    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    11h 15m
    $231–440

  2. Drive 599.9 mi

    cheapest
    1. Drive from Detroit to Kirksvillecar car 599.9 mi
    11h 25m
    $110–159

  3. Bus, train (Amtrak)

    1. Take the bus from Detroit to Chicago Union Stationbus bus Amtrak Thruway Connecting Service
    2. Take the train from Chicago Union Station to La Plata Stationtrain train Southwest Chief
    12h 52m
    $236–396

  4. Drive to Capital Region International Airport, fly to Kirksville Regional Airport

    1. Drive from Detroit to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Kirksville Regional Airport (IRK)plane plane LAN - IRK
    8h 25m
    $232–719

  5. Bus, train via Indianapolis

    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Galesburgbus bus
    3. Take the train from Galesburg Amtrak Station to La Plata Stationtrain train
    15h
    $162–300

  6. Fly Detroit to Kirksville Regional Airport

    1. Fly from Detroit (DTW) to Kirksville Regional Airport (IRK)plane plane DTW - IRK
    6h 12m
    $217–747

  7. Fly Detroit to Kansas City, train

    1. Fly from Detroit (DTW) to Kansas City (MCI)plane plane DTW - MCI
    2. Take the train from Kansas City to La Plata Stationtrain train
    9h 29m
    $477–1,252

  8. Bus to Bishop International Airport, fly to Kirksville Regional Airport

    1. Take the bus from Detroit Bus Station to Flintbus bus
    2. Fly from Bishop International Airport (FNT) to Kirksville Regional Airport (IRK)plane plane FNT - IRK
    13h 29m
    $185–611

  9. Fly Detroit to Chicago Midway International Airport, train

    1. Fly from Detroit (DTW) to Chicago Midway International Airport (MDW)plane plane DTW - MDW
    2. Take the train from Chicago Union Station to La Plata Stationtrain train
    10h 12m
    $277–725

  10. Fly Detroit to Lambert–St. Louis International Airport, shuttle

    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take a shuttle bus from St. Louis to Bowling Green, Moshuttle bus
    3. Take a shuttle bus from Bowling Green, Mo to Columbiashuttle bus
    4. Take a shuttle bus from Columbia to Hy-Vee - Kirksvilleshuttle bus
    10h 44m
    $466–973

Capital Region International Airport (LAN) to Kirksville Regional Airport (IRK) flights

Calendar13Weekly Planes
Duration9h 1mAverage Duration
Ticket$182Cheapest Price
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Questions & Answers

Map of how to get from Detroit to Kirksville.ExpandLaunch map view
  • Distance: 590.5 mi
  • Duration: 11h 15m

What companies run services between Detroit, MI, USA and Kirksville, MO, USA?

You can take a train from Detroit to Kirksville via Chicago Union Station and La Plata Station in around 11h 15m. Alternatively, Delta, Corporate Flight Management Inc, and American Airlines fly from Detroit (DTW) to Kirksville Regional Airport (IRK) 3 times a day.

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Train operators
Bus operators

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