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How to get fromDetroit to Knoxvilleby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

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There are 8 ways to get from Detroit to Knoxville by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Detroit (DTW) to Mcghee Tyson Airport (TYS)plane plane DTW - TYS
    3h 49m
    $177–822

  2. Drive 507.9 mi

    cheapest
    1. Drive from Detroit to Knoxvillecar car 507.9 mi
    8h 34m
    $93–134

  3. Bus via Toledo

    1. Take the bus from Detroit Bus Station to Toledo Bus Stopbus bus
    2. Take the bus from Toledo Bus Stop to New York Midtownbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    27h 46m
    $289–470

  4. Train, bus

    1. Take the train from Windsor to Aldershottrain train
    2. Take the train from Aldershot to New York Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    30h 19m
    $319–681

  5. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Detroit (DTW) to Chattanooga Metropolitan Airport (CHA)plane plane DTW - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    5h 28m
    $160–830

  6. Bus

    1. Take the bus from Detroit Bus Station to Port Authority Bus Terminalbus bus Greyhound US0420
    2. Take the bus from New York to Knoxvillebus bus Nyc
    29h 22m
    $296–466

  7. Bus, train via Farragut

    1. Take the bus from Detroit Bus Station to Toledo Bus Stopbus bus
    2. Take the train from Toledo to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    30h 49m
    $419–770

  8. Bus, train

    1. Take the bus from Detroit Bus Station to Toledo Bus Stopbus bus
    2. Take the train from Toledo to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    30h 53m
    $374–680

Detroit (DTW) to Mcghee Tyson Airport (TYS) flights

Calendar61Weekly Planes
Duration3h 28mAverage Duration
Ticket$129Cheapest Price
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Questions & Answers

Map of how to get from Detroit to Knoxville.ExpandLaunch map view
  • Distance: 478.1 mi
  • Duration: 3h 49m

What companies run services between Detroit, MI, USA and Knoxville, TN, USA?

Delta, American Airlines, and two other airlines fly from Detroit (DTW) to Mcghee Tyson Airport (TYS) every 3 hours. Alternatively, you can take a bus from Detroit Bus Station to Knoxville via Toledo Bus Stop, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 27h 46m.

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