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How to get fromDetroit to Mayo Clinicby plane, train, bus, bus (Flixbus), car, or bus (Amtrak)

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There are 10 ways to get from Detroit to Mayo Clinic by plane, train, bus, bus (Flixbus), car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Detroit to Rochester

    best
    1. Fly from Detroit (DTW) to Rochester (RST)plane plane DTW - RST
    6h 56m
    $77–422

  2. Bus to Bishop International Airport, fly to Rochester

    cheapest
    1. Take the bus from Detroit Bus Station to Flintbus bus
    2. Fly from Bishop International Airport (FNT) to Rochester (RST)plane plane FNT - RST
    8h 18m
    $70–356

  3. Train, bus via Milwaukee

    1. Take the train from Detroit to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Milwaukeetrain train
    3. Take the bus from Milwaukee to Rochesterbus bus
    14h 23m
    $189–344

  4. Bus

    1. Take the bus from Detroit Bus Station to Milwaukee Intermodal Stationbus bus FlixBus 2550
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson 966 / ...
    14h 28m
    $131–199

  5. Drive 627.5 mi

    1. Drive from Detroit to Mayo Cliniccar car 627.5 mi
    10h 23m
    $115–166

  6. Fly Detroit to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Detroit (DTW) to Minneapolis–Saint Paul International Airport (MSP)plane plane DTW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 39m
    $524–1,254

  7. Bus to Cleveland-Hopkins International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Minneapolis–Saint Paul International Airport (MSP)plane plane CLE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    9h 23m
    $630–1,103

  8. Train, bus

    1. Take the train from Detroit to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 9m
    $167–314

  9. Train, bus #2

    1. Take the train from Detroit to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    16h 15m
    $250–494

  10. Bus via Chicago

    1. Take the bus from Detroit to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    16h 27m
    $172–272

Detroit to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration16h 15mAverage Duration
Ticket$250Cheapest Price
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Questions & Answers

Map of how to get from Detroit to Mayo Clinic.ExpandLaunch map view
  • Distance: 506.7 mi
  • Duration: 6h 56m

What companies run services between Detroit, MI, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Detroit (DTW) to Rochester (RST) every 3 hours. Alternatively, you can take a bus from Detroit Bus Station to Mayo Clinic via Milwaukee Intermodal Station, Milwaukee, and Rochester in around 14h 28m.

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