There are 6 ways to get from Detroit to Murphysboro by plane, train (Amtrak), bus (Greyhound, Amtrak, Flixbus), car, bus, or bus (Flixbus, Amtrak)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Williamson County Regional Airport
best- Fly from Detroit (DTW) to Williamson County Regional Airport (MWA)plane DTW - MWA
6h 14m$122–492Drive 540.4 mi
cheapest- Drive from Detroit to Murphysborocar 540.4 mi
9h 26m$99–143Train (Amtrak)
- Take the train from Detroit to Chicago Union Stationtrain Wolverine
- Take the train from Chicago Union Station to Carbondaletrain Saluki / ...
11h 46m$212–417Bus
- Take the bus from Detroit Bus Station to Indianapolis Union Stationbus
- Take the bus from Indianapolis Union Station to St Louis Bus Stationbus
- Take the bus from St. Louis to Carbondalebus
13h 40m$113–230Fly to Lambert–St. Louis International Airport, bus
- Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane DTW - STL
- Take the bus from St. Louis to Carbondalebus
7h 19m$439–1,028Bus via Auburn Gresham
- Take the bus from Detroit Bus Station to Chicagobus
- Take the bus from Chicago to St Louis Bus Stationbus
- Take the bus from St. Louis to Carbondalebus
17h 10m$132–240
Detroit (DTW) to Williamson County Regional Airport (MWA) flights
Questions & Answers
The cheapest way to get from Detroit to Murphysboro is to drive which costs $95 - $150 and takes 9h 26m.
The fastest way to get from Detroit to Murphysboro is to fly which takes 6h 14m and costs $120 - $500.
No, there is no direct bus from Detroit station to Murphysboro. However, there are services departing from Detroit Bus Station and arriving at Carbondale via Indianapolis Union Station and St. Louis. The journey, including transfers, takes approximately 13h 40m.
No, there is no direct train from Detroit to Murphysboro. However, there are services departing from Detroit and arriving at Carbondale via Chicago Union Station. The journey, including transfers, takes approximately 11h 46m.
The distance between Detroit and Murphysboro is 473 miles. The road distance is 543.6 miles.
The best way to get from Detroit to Murphysboro without a car is to train which takes 11h 46m and costs $210 - $420.
It takes approximately 6h 14m to get from Detroit to Murphysboro, including transfers.
Detroit to Murphysboro bus services, operated by Greyhound USA, depart from Detroit Bus Station.
Detroit to Murphysboro train services, operated by Amtrak, depart from Detroit station.
The best way to get from Detroit to Murphysboro is to fly which takes 6h 14m and costs $120 - $500. Alternatively, you can train, which costs $210 - $420 and takes 11h 46m, you could also bus, which costs $110 - $230 and takes 13h 40m.
What companies run services between Detroit, MI, USA and Murphysboro, IL, USA?
American Airlines, United Airlines, and Corporate Flight Management Inc fly from Detroit (DTW) to Williamson County Regional Airport (MWA) 4 times a day. Alternatively, you can take a train from Detroit to Murphysboro via Chicago Union Station and Carbondale in around 11h 46m.
- Website
- southwest.com
Flights from Detroit to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- $100–600
Flights from Detroit to Lambert–St. Louis International Airport via Chicago Midway
- Ave. Duration
- 3h 30m
- When
- Tuesday to Friday
- Estimated price
- $100–600
Flights from Detroit to Lambert–St. Louis International Airport via Nashville
- Ave. Duration
- 3h 35m
- When
- Sunday
- Estimated price
- $130–700
- Website
- delta.com
Flights from Detroit to Lambert–St. Louis International Airport
- Ave. Duration
- 1h 37m
- When
- Every day
- Estimated price
- $100–600
- Website
- aa.com
Flights from Detroit to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 4h 7m
- When
- Every day
- Estimated price
- $75–430
- Website
- contouraviation.com
Flights from Detroit to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 4h 39m
- When
- Every day
- Estimated price
- $180–700
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Detroit to Chicago Union Station
- Ave. Duration
- 5h 6m
- Frequency
- 3 times a day
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
Train from Chicago Union Station to Carbondale
- Ave. Duration
- 5h 30m
- Frequency
- 3 times a day
- Estimated price
- $100–210
- Website
- https://www.amtrak.com/home.html
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Detroit Bus Station to Indianapolis Union Station
- Ave. Duration
- 5h 35m
- Frequency
- Once daily
- Estimated price
- $40–85
- Website
- https://www.greyhound.com/
Bus from Indianapolis Union Station to St Louis Bus Station
- Ave. Duration
- 3h 55m
- Frequency
- 3 times a day
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
Bus from St. Louis to Carbondale
- Ave. Duration
- 2h
- Frequency
- Once daily
- Estimated price
- $30–50
- Website
- https://www.amtrak.com/home.html
- Phone
- +1 (855) 626-8585
- Website
- https://www.flixbus.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $15–25
- Schedules at
- flixbus.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $15–25
- Schedules at
- flixbus.com
Bus from Detroit Bus Station to Chicago
- Ave. Duration
- 7h 15m
- Frequency
- Once daily
- Estimated price
- $50–90
- Schedules at
- flixbus.com
Bus from Chicago to St Louis Bus Station
- Ave. Duration
- 5h 45m
- Frequency
- 5 times a week
- Estimated price
- $45–80
- Schedules at
- flixbus.com
Bus from St. Louis to Carbondale
- Ave. Duration
- 1h 50m
- Frequency
- 5 times a week
- Estimated price
- $15–25
- Schedules at
- flixbus.com
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More Questions & Answers
Detroit to Murphysboro bus services, operated by Greyhound USA, arrive at Indianapolis Union Station.
Murphysboro is 1h behind Detroit. It is currently 2:48 AM in Detroit and 1:48 AM in Murphysboro.
Detroit to Murphysboro train services, operated by Amtrak, arrive at Chicago Union Station.
Yes, the driving distance between Detroit to Murphysboro is 544 miles. It takes approximately 9h 26m to drive from Detroit to Murphysboro.
Book your Detroit to Murphysboro train tickets online with Omio.
Book your Detroit to Murphysboro bus tickets online with Omio.
There are 34+ hotels available in Murphysboro.






