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How to get fromDetroit to Murphysboroby plane, train (Amtrak), bus (Greyhound, Amtrak, Flixbus), car, bus, or bus (Flixbus, Amtrak)

Find Transport to Murphysboro

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There are 6 ways to get from Detroit to Murphysboro by plane, train (Amtrak), bus (Greyhound, Amtrak, Flixbus), car, bus, or bus (Flixbus, Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Williamson County Regional Airport

    best
    1. Fly from Detroit (DTW) to Williamson County Regional Airport (MWA)plane plane DTW - MWA
    6h 35m
    $137–612

  2. Drive  539.6 mi

    cheapest
    1. Drive from Detroit to Murphysborocar car 539.6 mi
    9h 28m
    $96–138

  3. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to Carbondaletrain train Saluki / ...
    11h 46m
    $344–530

  4. Bus

    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St. Louis to Carbondalebus bus
    13h 40m
    $131–192

  5. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    7h 24m
    $159–801

  6. Bus via Auburn Gresham

    1. Take the bus from Detroit Bus Station to Chicagobus bus
    2. Take the bus from Chicago to St Louis Bus Stationbus bus
    3. Take the bus from St. Louis to Carbondalebus bus
    16h 35m
    $134–201

Detroit (DTW) to Williamson County Regional Airport (MWA) flights

Calendar24Weekly Planes
Duration4h 43mAverage Duration
Ticket$93Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Detroit to Murphysboro.ExpandLaunch map view
  • Distance: 470.4 mi
  • Duration: 6h 35m

What companies run services between Detroit, MI, USA and Murphysboro, IL, USA?

American Airlines, United Airlines, and Delta fly from Detroit (DTW) to Williamson County Regional Airport (MWA) 3 times a day. Alternatively, you can take a train from Detroit to Murphysboro via Chicago Union Station and Carbondale in around 11h 46m.

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