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How to get fromDetroit to O'Fallonby plane, train, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

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There are 6 ways to get from Detroit to O'Fallon by plane, train, bus (Greyhound), train (Amtrak), car, bus, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Detroit, train

    best
    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    5h 31m
    $456–956

  2. Bus

    cheapest
    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus Greyhound US0112
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    12h 7m
    $82–155

  3. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 25m
    $186–379

  4. Drive 508.6 mi

    1. Drive from Detroit to O'Falloncar car 508.6 mi
    8h 52m
    $93–135

  5. Bus to Cleveland-Hopkins International Airport, fly, train

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    3. Take the train from LAMBERT AIRPORT TERMINAL #1 station to SHILOH-SCOTT stationtrain train
    8h 10m
    $521–953

  6. Bus via Auburn Gresham

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    15h 37m
    $111–183

Detroit to O'Fallon by bus and train

Calendar7Weekly Services
Duration12h 7mAverage Duration
Ticket$82Cheapest Price
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Questions & Answers

Map of how to get from Detroit to O'Fallon.ExpandLaunch map view
  • Distance: 504.3 mi
  • Duration: 5h 31m

What companies run services between Detroit, MI, USA and O'Fallon, IL, USA?

You can take a bus from Detroit Bus Station to State @ Lincoln Eb via Indianapolis Union Station, St Louis Bus Station, CIVIC CENTER station, FAIRVIEW HEIGHTS station, and Fairview Heights Transit Center in around 12h 7m. Alternatively, you can take a train from Detroit to Lincoln @ 3Rd Street Nb via Chicago Union Station, St. Louis, CIVIC CENTER station, SHILOH-SCOTT station, and Shiloh-Scott Transit Center in around 12h 25m.

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