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How to get fromDetroit to Saint Charlesby plane, bus, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

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There are 7 ways to get from Detroit to Saint Charles by plane, bus, train (Amtrak), bus (Greyhound), car, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Detroit, line 34 bus

    best
    1. Fly from Detroit (DTW) to Lambert–St. Louis International Airport (STL)plane plane DTW - STL
    2. Take the bus from North Hanley Transit Center to 4375 Rider Trail North Sbbus bus
    4h 48m
    $672–976

  2. Bus (Greyhound)

    cheapest
    1. Take the bus from Detroit Bus Station to Indianapolis Union Stationbus bus Greyhound US0112
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    12h 37m
    $98–151

  3. Train (Amtrak)

    1. Take the train from Detroit to Chicago Union Stationtrain train Wolverine
    2. Take the train from Chicago Union Station to St. Louistrain train Lincoln Service / ...
    12h 26m
    $162–380

  4. Drive  532.2 mi

    1. Drive from Detroit to Saint Charlescar car 532.2 mi
    9h 9m
    $98–141

  5. Drive to Capital Region International Airport, fly

    1. Drive from Detroit to Lansing-Airport-LANcar car
    2. Fly from Capital Region International Airport (LAN) to Lambert–St. Louis International Airport (STL)plane plane LAN - STL
    6h 43m
    $112–508

  6. Bus to Cleveland-Hopkins International Airport, fly

    1. Take the bus from Detroit Bus Station to Cleveland Bus Stationbus bus
    2. Fly from Cleveland-Hopkins International Airport (CLE) to Lambert–St. Louis International Airport (STL)plane plane CLE - STL
    7h 21m
    $538–966

  7. Bus via Auburn Gresham (Flixbus)

    1. Take the bus from Detroit Bus Station to Chicagobus bus FlixBus 2552
    2. Take the bus from Chicago to St Louis Bus Stationbus bus FlixBus N2521
    14h 59m
    $116–170

Detroit (DTW) to Lambert–St. Louis International Airport (STL) flights

Calendar48Weekly Planes
Duration2h 16mAverage Duration
Ticket$101Cheapest Price
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Comparing Your Travel Options

Map of how to get from Detroit to Saint Charles.ExpandLaunch map view
  • Distance: 480.5 mi
  • Duration: 4h 48m

What companies run services between Detroit, MI, USA and Saint Charles, MO, USA?

You can take a train from Detroit to Saint Charles via Chicago Union Station, St. Louis, CIVIC CENTER station, NORTH HANLEY station, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 12h 26m. Alternatively, you can take a bus from Detroit Bus Station to Saint Charles via Indianapolis Union Station, St Louis Bus Station, Civic Center Transit Center, North Hanley Transit Center, and 4375 Rider Trail North Sb in around 12h 37m.

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